Research progress on coagulation abnormalities in multiple myeloma
10.12354/j.issn.1000-8179.2025.20241312
- VernacularTitle:多发性骨髓瘤凝血功能异常的研究进展
- Author:
Zeng QIANMIN
1
;
Zhao JIEJUN
;
Xi YAMING
Author Information
1. 兰州大学第一临床医学院(兰州市 730000)
- Publication Type:Journal Article
- Keywords:
multiple myeloma(MM);
bleeding;
thrombosis;
prophylaxis
- From:
Chinese Journal of Clinical Oncology
2025;52(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is a malignancy characterized by the abnormal proliferation of clonal plasma cells.It is often associated with coagulation abnormalities,posing risks of thrombosis,thromboembolism,and bleeding,including severe cases,which are related to de-creased quality of life,delayed or discontinued treatment,and reduced survival.Disease,individual-specific factors,and therapeutic agents affect the dynamic balance of coagulation,anticoagulation,and fibrinolytic systems in patients with MM.The diagnosis and treatment of un-derlying coagulation disorders are challenging due to the involvement of multiple mechanisms.In addition,newly introduced therapies such as immunomodulatory drugs,proteasome inhibitors,chimeric antigen receptor-modified T-cell therapy,and monoclonal antibodies also im-pact coagulation in patients with MM.This review discusses the influencing factors,pathophysiological mechanisms,and prevention and treatment strategies for coagulation abnormalities in MM.
