Correlations between left atrial myocardial strain and left ventricular function in children with Duchenne muscular dystrophy
10.13929/j.issn.1003-3289.2025.03.014
- VernacularTitle:进行性假肥大性肌营养不良患儿左心房心肌应变与左心室功能的相关性
- Author:
Yang FENG
1
;
Jiaqi SHEN
1
;
Li FAN
1
;
Jiamin XIA
1
;
Chunmei YIN
1
;
Chunjiang YANG
1
Author Information
1. 重庆医科大学附属儿童医院超声科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿童神经发育与认知障碍重庆市重点实验室,重庆 400014
- Publication Type:Journal Article
- Keywords:
muscular dystrophy,Duchenne;
ventricular function,left;
atrial function,left;
echocardiography;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(3):414-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlations between left atrial myocardial strain and left ventricular function in children with Duchenne muscular dystrophy(DMD).Methods Fifty-one DMD children(DMD group)and 42 healthy one(control group)were prospectively enrolled.The parameters of routine ultrasound and three-dimensional speckle-tracking echocardiography(3D-STE)were compared between groups,and the correlations between left atrial strain parameters and left ventricular function parameters were analyzed.Results The mitral annular lateral wall velocity(e'),left ventricular ejection fraction(LVEF),left atrial ejection fraction(LAEF),left atrioventricular coupling index(LACI),left ventricular global longitudinal strain(LVGLS),left atrial strain during reservoir phase(LASr)and left atrial strain during conduit phase(LAScd)were all lower,while mitral early diastolic peak flow velocity/e'(E/e'),left atrial stiffness index(LASI)and left atrial filling index(LAFI)were higher in DMD group than those in control group(all P＜0.05).In DMD group,LAEF,LASr and LAScd were moderately positively correlated with LVGLS(r=0.409,0.437,0.440,all P＜0.05),LAFI and LASI were weakly negatively correlated with LVGLS(r=-0.207,-0.223,both P＜0.05),while LASr was moderately positively correlated with e'(r=0.419,P＜0.05).Conclusion The left atrial myocardial strain was correlated with left ventricular systolic and diastolic function in DMD children.
