Impact factors of vascular heat sink effect during in vitro microwave ablation of porcine lung
10.13929/j.issn.1003-3289.2025.03.008
- VernacularTitle:微波消融离体猪肺血管热沉效应的影响因素
- Author:
Zenan CHEN
1
;
Zhongliang ZHANG
;
Sibin WANG
;
Xinyuan GUO
;
Jing ZHANG
;
Xiaobo ZHANG
;
Xiaofeng HE
;
Liangliang MENG
;
Xin ZHANG
;
Yingtian WEI
;
Yueyong XIAO
;
Qun NAN
;
Xiao ZHANG
Author Information
1. 中国人民解放军医学院研究生院,北京 100853;中国人民解放军总医院第一医学中心放射诊断科,北京 100853
- Publication Type:Journal Article
- Keywords:
animal experimentation;
swine;
lung;
blood vessels;
ablation techniques;
heat sink effect
- From:
Chinese Journal of Medical Imaging Technology
2025;41(3):383-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact factors of vascular heat sink effect during in vitro microwave ablation(MWA)of porcine lung.Methods Simulation models were established using in vitro porcine lung tissue blocks based on isobaric inflation with an air pump and cyclic perfusion of duck blood with a glass tube and peristaltic pump,etc.MWA was performed under 8 different combining conditions(vessel diameter of 3 or 5 mm,blood perfusion of 30 or 50 cm/s,as well as distance between vessel and ablation antenna of 5 or 10 mm)each for 3 times.The highest temperature TV on vessel side and TC on control side during MWA,and ablation depth DV on vessel side and DC on control side after MWA were recorded.Multi-factor linear regression equations were constructed based on simulated vessel diameters,blood perfusion and distance between vessel and ablation antenna,and the impact factors of|TC-TV|and|DC-DV|were screened,respectively.Results Simulated vessel diameter showed linear positive correlation with both|TC-TV|and|DC-DV|(both P＜0.001).Simulated distance between vessel and ablation antenna showed linear negative correlation with both|TC-TV|and|DC-DV|(both P＜0.001),and the latter had more obvious impact on vascular heat sink effect than the former.Meanwhile,no significant linear relationship was found between simulated blood perfusion and|TC-TV|nor|DC-DV|(both P＞0.05).Conclusion Simulated vessel diameter and distance between vessel and ablation antenna were both impact factors of vascular heat sink effect during in vitro MWA of porcine lung,and the latter was more influential,whereas simulated blood perfusion showed no significant impact on it.
