Association between neuroimaging changes and osteonecrosis:a large sample analysis from UK Biobank and FinnGen databases
- VernacularTitle:神经影像学变化与骨坏死的关联:UK Biobank及FinnGen数据库的大样本分析
- Author:
Bochun ZHANG
1
;
Wei LI
;
Guangzheng LI
;
Haoqin DING
;
Gang LI
;
Xuezhen LIANG
Author Information
- Publication Type:Journal Article
- Keywords: neuroimaging; osteonecrosis; causality; Mendelian randomization; engineered tissue construction
- From: Chinese Journal of Tissue Engineering Research 2025;29(30):6574-6582
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:With the continuous exploration of the pathogenesis of osteonecrosis,more and more research evidence shows that neuroimaging change is closely related to the onset of osteonecrosis.However,the specific causal relationship between neuroimaging change and osteonecrosis is still unclear.OBJECTIVE:To evaluate the causal relationship between neuroimaging indices and osteonecrosis using Mendelian Randomization analysis.METHODS:Neuroimaging data were obtained from the UK Biobank database in the UK,which included a total of 36 778 individuals.Osteonecrosis data were obtained from the FinnGen database in Finland,including 1 543 cases and 391 037 controls.Instrumental variables were extracted and screened from outcome factors,and two-sample Mendelian randomization analysis was performed.The data were analyzed by inverse variance weighted method,MR-Egger,weighted median method,simple model method,and weighted model method.The inverse variance weighted method was used as the main analysis method,and the other four methods were used as supplements.To verify the feasibility and stability of the data,sensitivity analysis of the results was performed.Based on the complexity of causal inference,a reverse Mendelian randomization analysis was further performed to evaluate the potential reverse causal relationship.RESULTS AND CONCLUSION:(1)The results of inverse variance weighted analysis showed that 97 neuroimaging data were positively correlated with osteonecrosis(P＜0.05,OR＞1);2 data were heterogeneous and 6 data had horizontal pleiotropy.95 neuroimaging phenotypes were negatively correlated with osteonecrosis(P＜0.05,OR＜1);5 data were heterogeneous,and 9 data had horizontal pleiotropy;2 groups of data had reverse causal relationships.(2)The two-sample Mendelian randomization analysis established the causal relationship between neuroimaging indicators and osteonecrosis in the academic community.These large sample numbers from the UK and Finland provide a new theoretical basis for the pathophysiology of osteonecrosis,and also provide ideas and methods for the prediction,screening,early diagnosis and prognosis of osteonecrosis in China,which is conducive to improving the accuracy of clinical diagnosis and the effectiveness of treatment of osteonecrosis.
