Associated factors of post-discharge depressive symptom severity in patients with bipolar disorder
10.3969/j.issn.1000-6729.2025.05.02
- VernacularTitle:双相障碍患者出院后抑郁症状程度的关联因素
- Author:
Wenge CHU
1
;
Xuanlian SHENG
;
Tingting ZHANG
;
Laitian ZHAO
;
Zhaorui LIU
;
Yan CHEN
;
Junjie HUANG
;
Fengling HU
;
Shuai WANG
;
Xiaohong XU
;
Yueqin HUANG
Author Information
1. 铜陵市第三人民医院,安徽铜陵 244000
- Publication Type:Journal Article
- Keywords:
bipolar disorder;
depressive symptom;
associated factor;
Hamilton Depression Scale
- From:
Chinese Mental Health Journal
2025;39(5):392-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore associated factors of post-discharge depressive symptom severity in patients with bipolar disorder.Methods:A longitudinal follow-up was conducted to investigate the demographic,behavioral,and clinical characteristics,and social function among discharged patients with bipolar disorder who met the DSM-5 diagnostic criteria.Clinical characteristics were assessed with the Hamilton Depression Scale(HAMD)and Brief Psychiatric Rating Scale(BPRS).Single factor and multivariate regression were carried out to explore the associat-ed factors of depressive symptom severity in patients with bipolar disorder.Results:A total of 298 discharged pa-tients with bipolar disorder were face-to-face interviewed to complete the follow-up survey.At follow-up time,psy-chotic symptoms(standardized(β)=0.18),housework((β)=0.23),social interaction((β)=0.17)and BPRS total score((β)=0.46)were positively associated with HAMD total score.Productive labor and work((β)=-0.27)and person-al life management((β)=-0.15)were negatively associated with HAMD total scores.Conclusion:Post-discharge depressive symptom severity in bipolar disorder patients is influenced by multiple factors.Effective management of psychotic symptoms,combined with enhanced community-based social rehabilitation and functional recovery,may help reduce the persistence or worsening of depressive symptoms and improve prognosis.
