Correlation between SIRT1/NF-κB signaling pathway and cognitive impairment in patients with Parkinson's disease
10.3969/j.issn.1673-9701.2025.08.008
- VernacularTitle:帕金森病患者SIRT1/NF-κB信号通路与认知功能障碍的相关性
- Author:
Lixia ZHANG
1
;
Zegao LANG
1
;
Hui WANG
1
Author Information
1. 台州市第二人民医院神经内科,浙江天台 317200
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
SIRT1/NF-κB signaling pathway;
Cognitive impairment
- From:
China Modern Doctor
2025;63(8):28-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation and diagnostic significance of the silent information regulator 2 related enzyme 1(SIRT1)/nuclear factor kappa B(NF-κB)signaling pathway and cognitive impairment(CI)in patients with Parkinson's disease(PD).Methods A total of 119 patients with primary PD diagnosed and treated be in Taizhou Second People's Hospital from September 2017 to March 2021 were selected as PD group.According to cognitive function status of subjects,research subjects were divided into normal cognitive(NC)group(n=33),mild cognitive impairment(MCI)group(n=58),and dementia subgroup(PDD)group(n=28).In addition,50 healthy people for physical examination during the same period were selected as normal control group.After admission,the peripheral blood levels of SIRT1/NF-κB signaling pathway related molecules in all subjects were detected,and relationship between expression of SIRT1/NF-κB signaling pathway and cognitive function in PD patients was analyzed by partial correlation analysis.Cox proportional hazards regression model was used to analyze the influencing factors,and receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of the SIRT1/NF-κB signaling pathway.Results SIRT1 mRNA expression in PD group was significantly lower than normal control group,while NF-κB mRNA expression was higher than normal control group(P＜0.05).PD group was further stratified and compared,and it was found that SIRT1 mRNA expression of PDD patients was significantly lower than that of NC and MCI patients(P＜0.05).SIRT1 mRNA and NF-κB mRNA had significant correlation with MoCA score(r=0.637,-0.527,P＜0.05).Cox regression analysis showed that high H-Y staging and high expression of NF-κB mRNA were independent risk factors for occurrence of CI in PD patients,and high expression of SIRT1 mRNA and high education level were independent protective factors for PD patients.ROC curve analysis showed that SIRT 1 and NF-κB mRNA expression diagnosed secondary CI in PD patients,and both had good predictive effects(P＜0.05).Conclusion SIRT1 mRNA and NF-κB mRNA were highly expressed in the peripheral blood of patients with PD secondary to CI,and had strong correlation with cognitive function.Early enhancement of the detection of SIRT1 mRNA and NF-κB mRNA expression in peripheral blood of PD patients can play an important role in diagnosis and prognosis.
