Dynamic changes in pulmonary function after pediatric haematopoietic stem cell transplantation
10.3969/j.issn.1673-9701.2025.08.009
- VernacularTitle:儿童造血干细胞移植后的肺功能动态变化分析
- Author:
Xiaowei ZHAO
1
;
Hongjuan LI
;
Yan GU
;
Yuqi ZHAO
;
Yanli LENG
;
Hongmei WANG
Author Information
1. 济宁医学院临床医学院,山东济宁 272067;山东第一医科大学第一附属医院(山东省千佛山医院)小儿血液科,山东济南 250014
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Pulmonary function;
Paediatric hematological disease
- From:
China Modern Doctor
2025;63(8):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes in pulmonary function after allogeneic hematopoietic stem cell transplantation(HSCT)in children and compare pulmonary function differences between children with benign and malignant hematological diseases.Methods A total of 233 children who underwent allogeneic HSCT in the First Affiliated Hospital of Shandong First Medical University,Shandong Provincial Qianfoshan Hospital from June 2015 to December 2023 were selected as subjects,according to the original disease,children were divided into benign group(n=142)and malignant group(n=91).Pulmonary function examination data were collected pre-transplant and at 3,6,9,12,18 and 24 months post-transplant,dynamic trajectories of pulmonary function parameters were analyzed.Results Forced expiratory volume in one second(FEV1)recovered after reaching its lowest in benign group in 6th month post-transplantation,while in malignant group in 9th month(P＜0.001).FEV1/forced vital capacity(FVC)reached its lowest value in 18th month and then recovered(P＜0.001).FEV1,FEV1/FVC,total lung capacity(TLC)and carbon monoxide diffusing capacity(DLCO)were significantly lower in malignant group than those in benign group at most time points(P＜0.05).Reduced DLCO was most common abnormality.Kaplan-Meier analysis showed that those with negative slopes of FEV1,FEV1/FVC,and FVC changes in first 3 months post-transplantation were more likely develop to restrictive ventilatory disorder,and those with negative FEV1/FVC slopes had a significantly higher risk of obstructive ventilatory disorder(P＜0.05).Conlusion Pulmonary dysfunction is prevalent in children after allogeneic HSCT.Pulmonary function parameters of children in malignant group were significantly lower than those in benign group and children recovery was slower.Patients with negative slopes of pulmonary function changes in the first 3 months after post-transplantation are more likely develop to pulmonary dysfunction.
