Predictive value of MRI imaging examination in secondary dementia of cognitive impairment of patients with Parkinson disease
10.3969/j.issn.1672-8270.2024.12.015
- VernacularTitle:MRI检查对帕金森病患者认知功能障碍继发痴呆的预测价值研究
- Author:
Ting SUN
1
;
Jianbing ZHU
;
Qing MA
;
Hongquan PANG
;
Wenjing XU
Author Information
1. 南京大学医学院附属苏州医院(苏州科技城医院)影像科 苏州 215000
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging (MRI);
Parkinson's disease (PD);
Cognitive impairment;
Secondary dementia prediction
- From:
China Medical Equipment
2024;21(12):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the predictive value of magnetic resonance imaging (MRI) examination in secondary dementia of cognitive impairment of patients with Parkinson disease (PD). Methods:A total of 100 PD patients with cognitive dysfunction,who admitted to the Affiliated Suzhou Hospital of Nanjing University Medical School and the Second Affiliated Hospital of Soochow University,were selected. They were divided into observation group (30 cases) and control group (70 cases) according to the Hasegawa Dementia Scale (HDS) score. The HDS score of observation group was ≤ 21.5 points,which had occurred secondary dementia,while the HDS score of control group was>21.5 points,which had not occurred secondary dementia. The imaging parameters,which included apparent diffusion coefficient (ADC) and fractional anisotropy (FA) index of magnetic resonance imaging (MRI),between two groups were compared. Logistic regression analysis was used to identify the risk factors for secondary dementia of PD patients with cognitive impairment. Receiver operating characteristic (ROC) curve was used to analyze the predictive efficacy of MRI imaging parameters for the secondary dementia of PD patients with cognitive impairment. Results:Compared with substantia nigra of the control group,the observation group had higher ADC values and lower FA values in substantia nigra,and the differences of them between the two groups were statistically significant (t=2.837,4.581,P<0.05),respectively. The ADC value and FA value of substantia nigra,age,PD duration and homocysteine (Hcy) were risk factors for the secondary dementia of cognitive impairment of PD patients (OR=1.537,1.346,1.134,1.351,1.625,P<0.05),respectively. The area under curve (AUC) value,sensitivity,specificity of the combined detection of ADC value and FA value of substantia nigra were respectively 0.861,94.86％ and 82.18％ in predict the secondary dementia of cognitive impairment of PD patients,and the predictive efficiency of combined detection was higher (95％CI:0.812-0.960,P<0.05). Conclusion:The increase of ADC value and the decrease of FA value of substantia nigra closely relate to the secondary dementia of cognitive dysfunction of PD patients. The combined detection of ADC value and FA value of substantia nigra can improve predictive efficiency of dementia.
