Analysis of the Characteristics of Prenatal Screening Results for Pregnant Women in Xinjiang
10.11969/j.issn.1673-548X.2025.03.017
- VernacularTitle:新疆地区孕妇血清学产前筛查结果特征分析
- Author:
Jian JIANG
1
;
Mengni SHEN
;
Wencheng DAI
Author Information
1. 830001 乌鲁木齐市妇幼保健院产前诊断中心
- Publication Type:Journal Article
- Keywords:
Xinjiang Uygur Autonomous Region;
Prenatal screening;
Median;
Nation;
Birth defect
- From:
Journal of Medical Research
2025;54(3):90-94,207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of serological prenatal screening results of pregnant women in Xinjiang,and pro-vide reference basis for the prevention and control of birth defects in Xinjiang.Methods The clinical data of 50781 pregnant women with singleton pregnancies who underwent mid-trimester serological prenatal screening at the Prenatal Diagnosis Center,Urumqi Maternal and Child Health Care Hospital from January 2022 to December 2023 were retrospectively analyzed.The levels of alpha-fetoprotein(AFP),free beta-chorionic gonadotropin(Freeβ-HCG)and free ultra Estriol(uE3)in the serum of pregnant women corresponding to different weight groups and pre-delivery age groups,and the differences in AFP,Freeβ-HCG and uE3 levels among 12 prefectures and 7 ethnic groups with the largest group of pregnant women were compared.Results The high-risk rate of serological prenatal screening in Xin-jiang was 6.00％,the prenatal diagnosis rate was 27.56％,and the positive predictive value was 1.84％.The levels of AFP,Freeβ-HCG and uE3 were inversely correlated with maternal weight and expected age before delivery.There were differences in the levels of AFP,Freeβ-HCG,uE3 in the serum of pregnant women from various prefectures and ethnic groups in Xinjiang(P＜0.05).Conclusion This study preliminarily determined the median of serological prenatal screening for AFP,Freeβ-HCG and uE3 in 12 prefectures and 7 permanent ethnic groups in Xinjiang.The prenatal screening center has revised the median system for prefectures and ethnic groups,which is of great significance for improving the service capacity of eugenics and childcare in Xinjiang.
