Influence of Diabetes on Infection and Cardiac Function in Elderly Patients with Pneumonia
10.11969/j.issn.1673-548X.2025.03.007
- VernacularTitle:糖尿病对老年肺炎患者感染及心功能的影响
- Author:
Qi KANG
1
;
Yifan CAO
;
Yuan YUAN
Author Information
1. 100035 首都医科大学附属北京积水潭医院老年医学科
- Publication Type:Journal Article
- Keywords:
LASSO regression;
Elderly patients with community-acquired pneumonia;
Diabetes mellitus;
Cardiac insufficiency;
Urinary tract infection
- From:
Journal of Medical Research
2025;54(3):28-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using the advantages of LASSO regression in early screening of complex diseases and judging disease condi-tions,to search a tool for early evaluation of cardiac insufficiency and infection in elderly people with community-acquired pneumonia(CAP)combined with diabetes mellitus(DM)to guide clinical practice.Methods According to the levels of the indexes at admission,the maximum level of the indexes during hospitalization and the level of the indexes at discharge were analyzed by multivariate analysis,and the differences of the core characteristic indexes were compared between the elderly patients with CAP combined with DM(CAP+DM)and those with CAP without DM(CAP alone)to discuss the necessity of biochemical indicators for predicting the development of core characteristics of two groups of patients.Results In elderly CAP+DM patients,the higher level of the blood white blood cell count at admission,the maximum levels of N terminal-pro B type natriuretic peptide(NT-pro BNP)and urine white blood cell count during hospitalization were higher.The higher the urine white blood cell count at admission,the maximum levels of blood white blood cell count and urine white blood cell count during hospitalization were higher.According to the NT-pro BNP,blood routine,and urine routine in-dexes at admission of elderly CAP patients,LASSO regression was performed on the maximum levels of core indexes during hospitalization and the levels of core indexes at discharge.It was found that after adding biochemical indexes,the determination coefficients of maximum levels of NT-pro BNP and urine white blood cell count during hospitalization and the NT-pro BNP level at discharge were significantly increased.Conclusion In elderly CAP+DM patients,the level of blood white blood cell count at admission can be used as a predictor of the severity of cardiac insufficiency during hospitalization.For elderly CAP+DM patients with higher blood white blood cell count and urine white blood cell count,attention should be paid to screen urinary tract infection during hospitalization.Biochemical tests at admis-sion can effectively help elderly CAP patients judge the severity of cardiac insufficiency and urinary tract infection during hospitalization and the cardiac function at discharge.
