Correlation study of PNI and DPN in patients with newly diagnosed T2DM
10.3969/j.issn.1673-9701.2025.08.007
- VernacularTitle:新诊断T2DM患者PNI与DPN的相关性研究
- Author:
Jiayao CAI
1
;
Yuhui PENG
1
;
Xue CHEN
1
;
Haifei ZHENG
1
;
Yi LIN
1
Author Information
1. 温州市人民医院上海大学附属第三医院内分泌科,浙江温州 325000
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellites;
Diabetic peripheral neuropathy;
Prognostic nutritional index
- From:
China Modern Doctor
2025;63(8):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic nutritional index(PNI)in patients with newly diagnosed type 2 diabetes mellites(T2DM)complicated with diabetic peripheral neuropathy(DPN).Methods A total of 300 patients with newly diagnosed T2DM from the Wenzhou People's Hospital during January 2017 to March 2023 were enrolled in this study.The patients were divided into uncomplicated DPN(n=214)and complicated DPN(n=86).The general data,biochemical indicators,PNI and other clinical indicators of the two groups were compared.According to PNI thirds,patients were divided into three groups:low,medium and high,comparing the proportion of DPN among the three groups;Logistic regression calculated the risk of DPN in different groups;Drawing receiver operating characteristic curve to analyze PNI and other indicators to predict the value of DPN.Results Compared with the non-DPN group,patients had lower PNI in the DPN group(P＜0.05);lower PNI was associated with higher risk of DPN(P＜0.001).Area under the curve of PNI was 0.882(95％CI:0.841-0.923,P＜0.001),and better predictive value of PNI for DPN than the systemic immune inflammation index,the neutrophil/lymphocyte ratio.Conclusion PNI is closely associated with the occurrence of DPN in newly diagnosed T2DM complicated,and PNI may be used as an important indicator for screening patients with T2DM complicated with DPN.
