Two sample Mendelian randomization study of causal relationship between education level and depression
10.3969/j.issn.1673-9701.2025.08.005
- VernacularTitle:双样本孟德尔随机化研究受教育程度与抑郁症的因果关系
- Author:
Chengxin SUN
1
;
Yinghao JIANG
;
Xiaoyan WANG
Author Information
1. 山东中医药大学第一临床医学院,山东济南 250014
- Publication Type:Journal Article
- Keywords:
Educational level;
Mendelian randomization;
Causal relationship;
Depression
- From:
China Modern Doctor
2025;63(8):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze causal relationship between education level and the occurrence of depression by using two sample Mendelian randomization(MR)study method.Methods The data of education level and depression were extracted from the Genome-Wide Association Study database,and the two-sample MR analysis was conducted,and sensitivity analysis was performed using the leave-one-out method.Results Ultimately,58 single nucleotide polymorphisms were successfully included.The results of bidirectional MR analysis showed that increase in education level can reduce the risk of depression(OR=0.95,95％CI:0.92-0.98,P＜0.01).MR-Egger regression and sensitivity analysis results showed that there was no horizontal pleiotropy in included single nucleotide polymorphisms(P＞0.05).Conclusion The risk of developing depression decreases with increasing education level.
