Antimicrobial resistance of Streptococcus strains isolated from dairy cow mastitis:a systematic review and meta-analysis
10.3969/j.issn.1002-2694.2025.00.030
- VernacularTitle:我国奶牛乳房炎链球菌对常用抗菌药物耐药性的Meta分析
- Author:
Xing-xing SI
1
;
Xiang-han XU
1
;
Xiao-ming WANG
1
;
Li-ping WANG
1
;
Jin-hu HUANG
1
Author Information
1. 南京农业大学动物医学院,南京 210095
- Publication Type:Journal Article
- Keywords:
dairy cow mastitis;
Streptococcus;
antimicrobial resistance;
meta-analysis
- From:
Chinese Journal of Zoonoses
2025;41(2):208-217
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at understanding the resistance status of dairy cow-derived Streptococcus strains in China,and providing scientific guidance for the rational use of antimicrobials and the development of new antimicrobials.Meta-analysis was used to explore the resistance of Streptococcus strains to 20 antimicrobials between 2000 and 2023.A total of 67 articles de-scribing 3 154 strains were included after a literature search,and a meta-analysis was conducted on the overall collection area according to time subgroups for 20 antimicrobials.Streptococci of dairy origin in China showed varying resistance rates(≥30％),as follows:penicillin(60％,95％CI=0.48-0.72),streptomycin(57％,95％CI=0.46-0.68),cotrimoxazole(56％,95％CI=0.28-0.82),lincomycin(51％,95％CI=0.26-0.76),tetracycline(49％,95％CI=0.40-0.59),doxycyc-line(42％,95％CI=0.24-0.60),clindamycin(41％,95％CI=0.28-0.54),ampicillin(39％,95％CI=0.27-0.52),e-rythromycin(37％,95％CI=0.28-0.45),kanamycin(36％,95％CI=0.20-0.54),and amoxicillin(30％,95％CI=0.10-0.53).On the basis of findings in the collection area,the resistance rates of dairy cow-derived Streptococcus to antimicrobials in Northeast China and Southwest China was generally high.The resistance rates of Streptococcus from dairy cattle to antimi-crobial drugs such as tetracycline,doxycycline,and lincomycin increased significantly over time.However,the resistance rates to antimicrobial drugs such as streptomycin,gentamicin,and enrofloxacin showed a significant decreasing trend.Dairy cow-de-rived Streptococcus had high resistance to some antimicrobials,and the resistance varied by region,because of differences in breeding and management.Monitoring of antimicrobial resistance rates,enhancing research on resistance mechanisms,and reg-ulating the use of antimicrobials remain necessary.
