mRNA vaccine molecular design,delivery,and molecular mechanisms of immune activation
10.3969/j.issn.1002-2694.2025.00.027
- VernacularTitle:mRNA疫苗-分子设计、递呈及免疫活化的分子机制
- Author:
Hui-min CHEN
1
;
Fei-fei LIU
1
;
Ke SHANG
1
;
Chun-jie ZHANG
1
;
Song-biao CHEN
1
Author Information
1. 河南科技大学动物科技学院/功能微生物与畜禽健康实验室,洛阳 471023;洛阳市活载体生物材料与动物疫病防控重点实验室,洛阳 471023;河南科技大学动物疫病与公共卫生重点实验室,洛阳 471023
- Publication Type:Journal Article
- Keywords:
mRNA vaccine;
molecular design;
delivery;
immune activation;
animal infectious diseases
- From:
Chinese Journal of Zoonoses
2025;41(2):186-192
- CountryChina
- Language:Chinese
-
Abstract:
Vaccine immunization is the most effective and cost-efficient method for infectious disease prevention and control.Since the outbreak of novel coronavirus pneumonia(caused by the novel coronavirus,COVID-19)at the end of 2019,third generation mRNA nucleic acid vaccines has been applied to stop viral spread.mRNA vaccines,rather than relying on the immune activation mode of traditional vaccines,are an innovative breakthrough using the body's own cells to produce antigens,thereby activating double specific immunity,forming immune memory,and providing more lasting specific immunity.Com-pared with the traditional first-generation(inactivated)and second-generation(genetically engineered)vaccines,mRNA vac-cines,because of the advantages provided by this platform,play important roles in the prevention and control of major sudden infectious diseases.Consequently,mRNA vaccines were the world's first COVID-19 vaccines to be applied clinically,thus ser-ving as a barometer in the field of vaccine research and development.Herein,the molecular design and presentation of mRNA vaccines,and the molecular mechanisms of their activation of the immune response are reviewed,to provide a theoretical basis for future application of novel mRNA vaccines in the prevention and control of animal infectious diseases.
