Relationship between macrophage activation related factors and clinical symptoms of schizophrenia
10.3969/j.issn.1000-6729.2025.01.01
- VernacularTitle:巨噬细胞活化相关因子与精神分裂症临床症状的关系
- Author:
Jiao FANG
1
;
Wenjin CHEN
;
Wenkai ZHENG
;
Mengzhuang GOU
;
Yongli LIU
;
Song CHEN
;
Na LI
;
Junchao HUANG
;
Yanli LI
;
Shujuan PAN
;
Yunlong TAN
Author Information
1. 内蒙古医科大学基础医学院,呼和浩特 010110;北京大学回龙观临床教学医院,北京 100096
- Publication Type:Journal Article
- Keywords:
schizophrenia;
interleukin-18;
α-N-acetylgalactosidase;
macrophage activating factor
- From:
Chinese Mental Health Journal
2025;39(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between macrophage activation related factors and clini-cal symptoms of schizophrenia(SCZ).Methods:Outpatient or inpatient SCZ patients(n=166)and normal con-trols(n=71)meeting the diagnostic criteria of DSM 4th edition were selected as subjects.The psychopathological symptoms were assessed by the Positive and Negative Syndrome Scale(PANSS),and the concentrations of α-Na-Galases,MAF and IL-18 were determined by enzyme-linked immunosorbent assay(ELISA).The correlation be-tween biological indicators and clinical symptoms was analyzed and the mediation effect was tested.Results:The concentrations of α-NaGalases(P＜0.001)and MAF(P＜0.01)in SCZ group were lower than those in normal control group.In SCZ group,IL-18 was negatively correlated with α-NaGalases concentration(r=-0.24,P＜0.01).α-NaGalases was positively correlated with MAF concentration(r=0.67,P＜0.001),and the total score of PANSS positive symptom scale was positively correlated with IL-18(r=0.21,P＜0.05)and MAF concentration(r=0.22,P＜0.01).The mediating effect of α-NaGalases and MAF was statistically significant,and the relative mediating effect accounted for 25.47％.Conclusion:The increase of IL-18 level may indicate the occurrence of positive symptoms of schizophrenia,and α-NaGalases and MAF may negatively regulate the inflammatory damage effect of IL-18 on SCZ,thereby reducing the positive symptoms.
