Correlation between SⅡ and early neurological deterioration in patients with branch atheromatous disease
10.3969/j.issn.1009-0126.2025.01.016
- VernacularTitle:全身免疫炎症指数与穿支动脉粥样硬化病患者神经功能恶化的相关性
- Author:
Debiao GAN
1
;
Juntao LI
;
Bing LIU
;
Junyan DUAN
;
Bo ZHANG
;
Zonghan JIA
;
Huiyong HUO
Author Information
1. 067000 承德医学院研究生院
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
systemic immune-inflammation index;
neurological deterioration;
branch atheromatous disease
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(1):72-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between systemic immune-inflammation index(SⅡ)at admission and occurrence of early neurological deterioration(END)in patients with branch atheromatous disease(BAD).Methods A retrospective analysis was performed on 326 BAD patients admitted in Department of Neurology of Handan Central Hospital from October 2021 to February 2024.Based on occurrence of END or not,they were divided into END group(97 cases)and non-END group(229 cases).Clinical data of the patients were collected,and multivari-ate logistic regression analysis was used to identify the END risk variables in BAD patients.ROC curve was plotted to evaluate the value of NIHSS score,hs-CRP and SⅡ in predicting the inci-dence of END in the patients.Results Significantly advanced age,higher NIHSS score at admis-sion,and elevated hs-CRP level,neutrophil count and SⅡ,but lower platelet and lymphocyte counts were observed in the END group than the non-END group(P＜0.05,P＜0.01).Multi vari-ate logistic regression analysis indicated that NIHSS score at admission(OR=1.134,95％CI:1.050-1.226,P=0.001),hs-CRP(OR=1.131,95％CI:1.024-1.249,P=0.015),and SⅡ(OR=1.001,95％CI:1.001-1.002,P=0.003)were independent risk factors for END in BAD patients.The AUC value of SⅡ in the prediction of END was 0.660,which was significantly higher than that of NIHSS score and hs-CRP in BAD patients(P＜0.05).Conclusion SⅡ is an independent risk factor for END in BAD patients,and SⅡ at admission has a certain predictive value for the oc-currence of END in these patients.
