Efficacy Evaluation and Prediction Model Construction of Radiofrequency Ablation for Single Papillary Thyroid Carcinoma with Calcifica-tion
10.11969/j.issn.1673-548X.2025.03.012
- VernacularTitle:单发含钙化甲状腺乳头状癌射频消融术疗效评估及预测模型构建
- Author:
Yiming LI
1
;
Lin YAN
1
;
Xinyang LI
1
Author Information
1. 100076 北京,中国人民解放军总医院第一医学中心超声诊断科
- Publication Type:Journal Article
- Keywords:
Radiofrequency ablation;
Papillary thyroid carcinoma;
Calcification
- From:
Journal of Medical Research
2025;54(3):62-67,84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy,safety and prognosis of ultrasound-guided radiofrequency ablation(RA)for single papillary thyroid carcinoma(PTC)with calcification.Methods A retrospective analysis was performed on 163 patients with calcified single PTC who received RFA treatment from January 1,2015 to December 31,2019.The patients who underwent RFA surgery before December 31,2016 were included in the training set,the others after January 1,2017 were included in the test set.With the non-disap-pearance of ablation at the last follow-up after RFA as the end event,the independent risk factors for non-disappearance of ablation were screened out by Logistic regression analysis,and a nomogram was constructed to evaluate the predictive efficacy and clinical value.The safety and efficacy of RFA in patients with calcified PTC were also evaluated.Results Multivariate Logistic regression analysis showed that age(P=0.001),maximum lesion diameter(P=0.021)and calcification ratio(P=0.048)were independent risk factors for non-disappearance of ablation.A nomogram model was established,the area under the area(AUC)of this model was 0.780 in the training set,and 0.711 in the test set.The calibration curve showed that the nomogram model predicted the outcome of the ablation site in good agreement with the real situation.Cinical decision analysis curve indicated a good clinical potential.In 163 lesions,there were 90 le-sions(55.2％)which with less calcification content in the nodules disappeared completely,no serious complications were observed,and the volume of ablation sites was continuously reduced,8 patients(4.9％)developed metastasis and recurred.Conclusion RFA has good safety and efficacy in the treatment of calcified PTC.The predictive model of the outcome of ablation lesion after RFA in patients with calcified single PTC constructed on the basis of age,maximum lesion diameter,and calcification ratio has good differentiation and calibra-tion,which can be used to assess the postoperative efficacy of RFA after RFA in patients with calcified single PTC.
