Mechanisms by which traditional Chinese medicine modulates the NF-κB signaling pathway to alleviate diabetic kidney disease
10.3969/j.issn.1671-7856.2025.02.014
- VernacularTitle:中医药调控NF-κB信号通路延缓糖尿病肾病进展概述
- Author:
Xin LI
1
;
Zhi PAN
Author Information
1. 长春中医药大学,长春 130117
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
NF-κB signaling pathway;
traditional Chinese medicine
- From:
Chinese Journal of Comparative Medicine
2025;35(2):131-138
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is a common complication of diabetes mellitus(DM)and a leading cause of end-stage renal disease(ESRD).Increasing evidence indicates that the nuclear factor-kappa B(NF-κB)signaling pathway plays a pivotal role in the onset and progression of DKD.Numerous experimental studies have demonstrated that traditional Chinese medicine can attenuate inflammatory responses by modulating the NF-κB signaling pathway,thereby delaying the progression of DKD.This review summarizes the relationship between the NF-κB signaling pathway and DKD,and discusses advances in research into how traditional Chinese medicine interventions targeting the NF-κB signaling pathway can alleviate DKD,with the aim of providing new references for targeted therapy of DKD.
