Research progress on the role and mechanisms of epigenetics in delirium diseases
10.3969/j.issn.1671-7856.2025.02.012
- VernacularTitle:表观遗传学在谵妄疾病中的作用和机制研究进展
- Author:
Xinyi XU
1
;
Changhong MIAO
;
Fangying WU
;
Lu XIAO
Author Information
1. 天津中医药大学第一附属医院急症部,国家中医针灸临床医学研究中心,天津 300381
- Publication Type:Journal Article
- Keywords:
delirium;
epigenetics;
non-coding RNA;
DNA methylation;
histone acetylation
- From:
Chinese Journal of Comparative Medicine
2025;35(2):116-123
- CountryChina
- Language:Chinese
-
Abstract:
Delirium has a high incidence and is associated with a poor patient prognosis.The pathogenesis of delirium is still unclear.Although antipsychotic drugs are the main intervention in clinical practice,there are currently no drugs that can definitively improve the long-term health-related quality of life in patients with delirium.In this study,we review research on the associations between epigenetic modifications such as non-coding RNAs,DNA methylation,and histone acetylation and the development of delirium,with the aim of providing information to support clinical decisions on the early identification and diagnosis of delirium,as well as its treatment and prognosis and the development of relevant targeted drugs.
