Interaction between perceived social support and TMEM161B gene rs768705 polymorphism and its association with risk of developing depression
10.3969/j.issn.1000-6729.2025.02.02
- VernacularTitle:领悟社会支持和TMEM161B基因rs768705多态性及其交互作用与新发抑郁症状的关联
- Author:
Xingmeng NIU
1
;
Hanyun LI
;
Xueyi WANG
;
Sifang NIU
;
Yan QIN
;
Yi ZHENG
;
Fuqin MU
;
Yueqin HUANG
;
Yan LIU
Author Information
1. 山东第二医科大学公共卫生学院,山东潍坊 261053;济宁医学院公共卫生学院,山东济宁 272013
- Publication Type:Journal Article
- Keywords:
depressive symptoms;
freshman;
perceived social support;
gene polymorphism;
interaction
- From:
Chinese Mental Health Journal
2025;39(2):107-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between perceived social support,TMEM161B gene rs768705 polymorphism,and their interaction with incidence of depressive symptoms in the freshmen.Methods:A total of 9928 freshmen from two medical universities were investigated at baseline and follow-up two years later during 2018-2020 by cluster sampling.A self-report demographic characteristics questionnaire was used to collect information of general demographic characteristics.Perceived Social Support Scale,Beck Depression Inventory,Beck Anxiety Inventory and Adolescent Self-Rating Life Events Check List were used to measure the level of perceived social support,depressive symptoms,anxiety symptoms and the number of negative life events of individuals.Blood sam-ples were collected and typed for DNA by professionals.Results:Family support and other support were all nega-tively associated with depressive symptoms in the freshmen(OR=0.96,95％CI:0.93-0.99;OR=0.94,95％CI:0.91-0.98).There was no correlation between friend support and depressive symptoms in the freshmen(OR=0.99,95％CI:0.95-1.02).TMEM161B gene rs768705 polymorphism(AG)was positively associated with de-pressive symptoms in the freshmen(OR=1.58,95％CI:1.12-2.23).The interactions of friend support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95％CI:1.02-1.26)and other support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95％CI:1.02-1.25)had significant effects on the incidence of depressive symptoms in the females and no significant effect in the males.Conclusion:The perceived social support,TMEM161B gene rs768705 polymorphism and their interaction are associated with influence of de-pressive symptoms,and have sex difference in the freshmen.
