Study on Common TCM Syndromes of Colorectal Cancer Based on Latent Structure Model Combined with Clustering Analysis
10.19879/j.cnki.1005-5304.202411138
- VernacularTitle:基于隐结构模型和聚类分析的结直肠癌常见中医证候研究
- Author:
Shuoqi ZHAO
1
;
Yuan YAO
;
Xiaohe SUN
;
Liu LI
;
Haibo CHENG
Author Information
1. 南京中医药大学第一临床医学院,江苏 南京 210003;南京中医药大学附属医院,江苏 南京 210003;江苏省中医药防治肿瘤协同创新中心,江苏 南京 210003
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
TCM syndrome;
literature research;
latent structure;
systematic clustering
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(4):51-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution characteristics of common TCM syndromes in colorectal cancer;To provide a basis for standardized research on syndrome of colorectal cancer.Methods The literature related to TCM syndromes of colorectal cancer was retrieved from CNKI,Wanfang Data,VIP and SinoMed.Information on syndrome types and symptoms was extracted to establish a traditional Chinese medicine syndrome database for colorectal cancer.Frequency statistics were used to analyze distribution of colorectal cancer syndrome types and their symptom characteristics.Lantern 5.0 software was used to establish a latent structure model based on the LTM-EAS algorithm,and factor analysis and systematic clustering analysis were conducted using SPSS 27.0 software to infer potential patterns.Based on the results of comprehensive frequency statistics,systematic clustering and latent structure analysis,common TCM syndrome types and symptom characteristics of colorectal cancer were obtained.Results A total of 929 articles were included,totaling 2 465 syndrome items,involving 97 syndrome types,with high frequency of qi-blood deficiency syndrome,dampness and heat accumulation syndrome,spleen-kidney yang deficiency syndrome,etc.,and 281 symptoms,including abdominal distension,anorexia,abdominal pain and mental fatigue,etc.The latent structure analysis obtained 23 hidden variables,and 8 common syndromes were obtained according to professional knowledge.Factor analysis obtained 17 common factors,and further systematic cluster analysis inferred 9 potential syndrome types.Conclusion Common syndrome of colorectal cancer can be divided into 9 types,which are dampness and heat accumulation syndrome,blood stasis toxicity internal obstruction syndrome,qi stagnation and blood stasis syndrome,dampness and heat stasis toxicity syndrome,spleen deficiency and phlegm-dampness syndrome,spleen qi deficiency syndrome,qi and blood deficiency syndrome,liver-kidney yin deficiency syndrome,and spleen-kidney yang deficiency syndrome.The symptom characteristics of each syndrome are significant,which can provide reference for clinical differentiation and lay foundation for standardized research on syndrome.
