The effect of abnormal lipid metabolism on immunosenescence of colonic lamina propria
10.3760/cma.j.issn.0254-9026.2025.06.006
- VernacularTitle:脂代谢异常对结肠黏膜固有层免疫衰老的影响
- Author:
Fangyuan CONG
1
;
Jingtong WANG
1
Author Information
1. 北京大学人民医院老年科，北京 100044
- Publication Type:Journal Article
- Keywords:
Intestinal mucosal barrier;
Immunosenescence;
Lipid metabolism;
High fat diet
- From:
Chinese Journal of Geriatrics
2025;44(6):717-721
- CountryChina
- Language:Chinese
-
Abstract:
The ageing of the adaptive immune system, mainly manifested by changes in the proportion of T cell subtypes, is the cause of various age-related diseases.As the largest immune system in the human, the intestinal mucosal immune system also undergoes adaptive immunosenescence, makes elderly vulnerable to various diseases and increases the risk of death.Metabolism plays an important role in immunosenescence, but the effect and mechanism of lipid metabolism on immunosenescence of intestinal mucosa are currently unclear.Our team focuses on Paget's nodus and lamina propria of colonic mucosa, which are important sites of intestinal immunity.The results show that abnormal lipid metabolism caused by high-fat diet can accelerate the immunosenescence of intestinal mucosa at different age groups.The effects of high-fat diet are more significant in the elderly, and statins may partially reverse the immunosenescence.This research provides new ideas for a deeper understanding and targeted therapy of immunosenescence.
