Endoplasmic reticulum stress and autophagy interaction in pathogenesis of postmenopausal osteoporosis
- VernacularTitle:内质网应激与自噬交互作用在绝经后骨质疏松发病中的研究进展
- Author:
Ru-na CHEN
1
;
Li-wei WEI
;
Shuang CHAI
;
Hong ZHANG
;
Na QIN
Author Information
- Publication Type:Journal Article
- Keywords: endoplasmic reticulum stress; autophagy; postm-enopausal osteoporosis; unfolded protein response; crosstalk; pathogenesis
- From: Chinese Pharmacological Bulletin 2025;41(4):626-631
- CountryChina
- Language:Chinese
- Abstract: The endoplasmic reticulum is an important organelle responsible for the synthesis,folding and processing of proteins.When the endoplasmic reticulum protein folding ability is affect-ed,internal unfolded proteins or misfolded proteins accumulate in the endoplasmic reticulum accumulation,leading to endoplasmic reticulum structural dysfunction resulting in endoplasmic reticu-lum stress.Autophagy is the process by which cells selectively remove stress endoplasmic reticulum and error proteins.Under stress,the endoplasmic reticulum can maintain normal physiolog-ical functions through unfolded protein responses and autophagy.Postmenopausal osteoporosis is mainly due to an imbalance be-tween bone resorption by osteoclasts and bone formation by oste-oblasts.Endoplasmic reticulum stress and autophagy both modu-late bone cells status with consequences for bone homeostasis.This article provides a review of the progress of research on en-doplasmic reticulum stress and autophagy interaction in the path-ogenesis of postmenopausal osteoporosis.
