Research progress in role of LncRNA in mechanisms related to cerebral ischemia/reperfusion injury

VernacularTitle:LncRNA与脑缺血/再灌注损伤相关机制的研究进展
Author: Zhipeng HUA ¹ ; Xue LYU ; Hao LI ; Zhanjun YANG ; Jianxin JIA ; Zhifu YANG
Author Information

1. 内蒙古科技大学包头医学院第一附属医院神经内科,内蒙古包头 014010;内蒙古科技大学包头医学院研究生院,内蒙古包头 014014
Publication Type:Journal Article
Keywords: LncRNA; ischemia/reperfusion injury; cerebral stroke
From: Chinese Journal of Comparative Medicine 2025;35(2):109-115
CountryChina
Language:Chinese
Abstract: Cerebral ischemia/reperfusion injury(CIRI)is a pathophysiological process affecting the prognosis of patients with acute ischemic stroke(AIS).Its mechanism is complex and remains unclear.Long non-coding RNA(LncRNA)are a class of non-coding RNA(ncRNA).Early studies of LncRNA focused on their relationship with tumor-related diseases,but recent studies have found that they are also closely related to the pathological process of CIRI.LncRNA participate in the damage and repair processes of CIRI by affecting oxidative stress,autophagy,and apoptosis of the nervous system,as well as the inflammatory response and other mechanisms.They can regulate the progression of CIRI in a positive or negative way,and they play an important role in the related signaling pathways.This review focuses on the mechanisms bv which LncRNA regulate CIRI.