Effects of branched-chain and aromatic amino acids on type 2 diabe-tes mellitus and the progress
10.12092/j.issn.1009-2501.2025.04.011
- VernacularTitle:支链氨基酸和芳香族氨基酸对2型糖尿病作用进展
- Author:
Mengli ZHANG
1
;
Fangfang WU
;
Zhien TAN
;
Min OU
;
Lingjie LIU
;
Na LU
;
Liya QIAO
;
Xia-onan YANG
Author Information
1. 广西壮族自治区药用植物园西南濒危药材资源开发国家工程研究中心,南宁 530023,广西
- Publication Type:Journal Article
- Keywords:
branched-chain amino acids;
aromat-ic amino acids;
metabolic disorders;
type 2 diabe-tes mellitus;
insulin resistance
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):526-532
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus is a metabol-ic disease characterized by high blood sugar levels.Traditionally,amino acids are primarily viewed as the basic building blocks for proteins and peptide synthesis.However,in recent years,amino acids have gained increased attention as signaling mole-cules that play crucial roles in the maintenance and regulation of metabolic homeostasis.It has been found that there is a close correlation between the metabolism of branched-chain and/or aromatic amino acids and the occurrence or development of type 2 diabetes mellitus.Furthermore,there have been successive reports on the regulation mecha-nism involved.This article will focus on the meta-bolic processes,mechanisms and clinical value of branched-chain and aromatic amino acids in type 2 diabetes mellitus.It will also summarize and pro-vide an outlook on the current state of amino acid metabolism in the treatment of diabetes mellitus,with the aim of offering new ideas for the treat-ment of type 2 diabetes mellitus.
