Evaluation of anticholinergic medications at discharge in elderly patients with chronic heart failure
10.3969/j.issn.1009-0126.2025.03.009
- VernacularTitle:老年慢性心力衰竭患者出院带药抗胆碱能药物评价
- Author:
Fangfang ZHENG
1
;
Jingjing JIN
;
Yanli REN
;
Chunying ZHANG
;
Mei ZHAO
;
Shuang SUN
;
Hong CHEN
;
Junxian SONG
Author Information
1. 100044 北京大学人民医院心血管内科
- Publication Type:Journal Article
- Keywords:
heart failure;
cholinergic antagonists;
drug-related side effects and adverse reactions;
accidental falls
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(3):294-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the use of anticholinergic medications at discharge among elderly patients with chronic heart failure(CHF)and its associated risk factors.Methods Clinical data of 240 elderly CHF patients admitted in our Department of Cardiovascular Diseases between January 1,2020,and December 31,2023 were colloected.Based on ACB score,they were divided into an an-ticholinergic group(ACB score≥1,223 cases)and a non-anticholinergic group(ACB score of 0,17 cases).Using the ACB score,the anticholinergic burden was quantified,and the relationship be-tween anticholinergic burden and various related factors was analyzed using logistic regression.Results The anticholinergic group had significantly younger age[(75.17±7.21)years vs(79.12±8.75)years,P＜0.05],and larger number of discharge medications[8(6,10)vs 5(4,7),P＜0.01]when compared with the non-anticholinergic group.Logistic regression analysis showed that the number of discharge medications was an independent risk factor for increased anticholinergic bur-den in the elderly CHF patients(OR=1.575,95％CI:1.249-1.986,P=0.001).Conclusion The proportion of elderly CHF patients using anticholinergic medications is relatively high.Clinically,special attention should be given to polypharmacy to reduce the incidence of adverse events caused by anticholinergic drugs.
