Correlation of metabolic comorbidities and insulin resistance with CKD in an elderly population taking physical exam
10.3969/j.issn.1009-0126.2025.03.002
- VernacularTitle:老年健康查体人群中代谢相关共病及胰岛素抵抗与慢性肾脏病的相关性研究
- Author:
Guang YANG
1
;
Bokai CHENG
;
Xin SHEN
;
Yang LIU
;
Ying DING
;
Qingli CHENG
;
Yansong ZHENG
;
Jiahui ZHAO
Author Information
1. 100853 北京,解放军总医院第二医学中心肾脏病科国家老年疾病临床研究中心
- Publication Type:Journal Article
- Keywords:
multiple chronic conditions;
metabolic diseases;
insulin resistance;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(3):260-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of metabolic comorbidities and insulin resistance(IR)with chronic kidney disease(CKD)among elderly individuals undergoing health exam.Methods A cross-sectional observational study was conducted on 8358 older adults who took health exam in Chinese PLA General Hospital between December 2009 and May 2021.According to the guidelines for CKD diagnostic criteria,they were divided into CKD group(983 cases)and non-CKD(7375 cases).Clinical data was collected,and the eGDR was calculated.Quasi-Bayesian method was used for causal mediation analysis.Results The prevalence of metabolic comorbidi-ties including hypertension,CHD,DM,hyperlipidemia,and hyperuricemia was significantly higher in the CKD group than the non-CKD group(P＜0.01).The eGDR was obviously lower in the CKD group than the non-CKD group[6.88±2.09 mg/(kg·min)vs 8.41±2.12 mg/(kg·min),P＜0.01].Logistic regression analysis revealed that,without adjusting covariates,each 1-unit increase in eGDR was associated with a 29％reduction in the risk of developing CKD(OR=0.714,95％CI:0.691-0.738,P＜0.01),and after adjusting covariates,eGDR remained signifi-cantly negatively association with the risk of CKD(P＜0.01).Mediation analysis indicated that DM and brachial-ankle pulse wave velocity accounted for the highest proportions of the mediating effect in the relationship between eGDR and CKD(14.2％and 12.5％,respectively).Conclusion In the elderly population undergoing health exam,reduced insulin sensitivity is significantly asso-ciated with the development of CKD.Diabetes and arteriosclerosis exert mediating effect in this association.
