Expert consensus on the model informed precision dosing of tacroli-mus in patients receiving anti-rejection therapy

VernacularTitle:模型引导的抗排异治疗患者他克莫司精准用药专家共识
Author: Bing CHEN ¹ ; Xiaocong ZUO ; Xingang LI ; Dewei SHANG ; Peijun ZHOU ; Junjie DING ; Xiaoq-iang XIANG ; Xiaoyan QIU ; Zhuo WANG ; Xiaoyu LI ; Yi ZHANG ; Wei ZHAO ; Yuzhu WANG ; Jianjun GAO ; Zheng JI-AO
Author Information

1. 上海交通大学医学院附属瑞金医院
Publication Type:Journal Article
Keywords: tacrolimus; model informed preci-sion dosing(MIPD); therapeutic drug monitoring(TDM); consensus
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(4):433-445
CountryChina
Language:Chinese
Abstract: There is significant inter-individual variation of pharmacokinetics and pharmacody-namics in patients receiving tacrolimus(TAC)for an-ti-rejection therapy,which cause the rejection or toxic action.Based on results of therapeutic drug monitoring and pathophysiological index of trans-plant patients,the individualized dosing regimen can be designed and adjusted by using model in-formed precision dosing(MIPD).The patients'clini-cal outcome can be improved.In the consensus,the different methods of MIPD used for patients re-ceived TAC for anti-rejection therapy were intro-duced,which can be used for the designing and ad-justing doing regimen,predicting adverse drug reac-tion,improving medication adherence and econom-ics during therapy.