A randomized controlled trial of value orientation brief therapy combined with selective serotonin reuptake inhibitors in mild to moderate depression
10.3969/j.issn.1000-6729.2025.03.01
- VernacularTitle:价值取向短程治疗联合抗抑郁药治疗轻中度抑郁症的随机对照试验
- Author:
Ziyang JI
1
;
Lijing SHI
;
Yifang FU
;
Yixuan ZHANG
;
Meiqi SHAO
;
Manyu HE
;
Jiao DONG
;
Fengju YAO
;
Huiying WANG
;
Changhong WANG
Author Information
1. 新乡医学院第二附属医院精神科,河南省睡眠医学重点实验室,精神心理疾病防治河南省协同创新中心(新乡医学院第二附属医院),河南新乡 453002
- Publication Type:Journal Article
- Keywords:
value orientation brief therapy;
depression;
decision making ability;
rumination thinking;
cogni-tive function
- From:
Chinese Mental Health Journal
2025;39(3):193-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of value orientation brief therapy(VBT)combined with selective serotonin reuptake inhibitors(SSRIs)on clinical symptoms,rumination,decision-making ability,and cognitive func-tion in patients with mild to moderate depression.Methods:Eighty patients meeting the DSM-5 diagnostic criteria for mild to moderate depression were randomly assigned to either a medication(SSRIs)group(36 completed)or a VBT combined group(38 completed)for a 6-week intervention.Baseline and post-intervention assessments includ-ed the Hamilton Depression Scale(HAMD),Hamilton Anxious Scale(HAMA),Ruminative Response Scale-Chi-nese Version(RRS-CV),Iowa Gambling Test(IGT),number of eye fixation(NEF),responsive search score(RSS)in exploratory eye trajectory movement were used to evaluate patients'anxiety and depression symptoms,ru-minative thinking,decision-making function,and cognitive function.Results:The VBT combined group showed sig-nificantly better therapeutic effects than the medication group(P＜0.05).Compared to baseline and the medication group,the VBT combined group had significantly lower post-intervention scores in HAMD,HAMA,symptom rumi-nation,introspective reflection,compulsive meditation,and RRS-CV total scores after intervention(Ps＜0.05),and significantly higher scores in IGT net profit scores,NEF,and RSS scores(Ps＜0.05).Compared with the medica-tion group,the VBT combined group demonstrated a greater reduction in HAMD,HAMA,symptom rumination,in-trospective reflection,compulsive meditation,and RRS-CV total scores before and after intervention(Ps＜0.05),and a larger increase in IGT net profit scores,NEF,and RSS scores(Ps＜0.05).Conclusion:VBT combined with SSRIs effectively improves the symptoms of depression,anxiety,decision-making ability,rumination thinking,and cognitive function in patients with mild to moderate depression.
