Relationship of fetuin-A and matrix Gla protein with coronary artery calcification and prognosis in elderly patients with ACS
10.3969/j.issn.1009-0126.2025.03.007
- VernacularTitle:胎球蛋白A和基质Gla蛋白与老年急性冠状动脉综合征冠状动脉钙化及预后的关系
- Author:
Sha LIU
1
;
Mei WANG
;
Shasha ZANG
Author Information
1. 071000 保定,河北大学附属医院心血管内科
- Publication Type:Journal Article
- Keywords:
alpha-2-HS-glycoprotein;
acute coronary syndrome;
vascular calcification
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(3):285-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of fetuin-A and MGP with the degree of coro-nary artery calcification and prognosis in elderly patients with ACS.Methods A total of 187 eld-erly ACS patients admitted to our hospital from June 2021 to June 2023 were recruited in this study.All of them underwent coronary CT examination,and the prognosis at 1 year after treat-ment was statistically analyzed.According to their CACS of coronary CT,the patients were divid-ed into non-calcification group(50 cases),and mild,moderate and severe calcification groups(67,43 and 27 cases,respectively).They were also assigned into poor(58 cases)and good prognosis groups(129 cases)according to the prognosis.Serum fetuin-A and MGP levels were compared be-tween above groups.Pearson correlation analysis was used to analyze the correlation between CACS and fetuin-A as well as MGP levels.Multivariate logistic regression analysis was conducted to identify the prognostic factors in the elderly ACS patients.ROC curve was plotted to evaluate the predictive value of fetuin-A and MGP for poor prognosis in the patients.Results The serum fetuin-A and MGP levels were gradually decreased in the non-calcification group,and then fol-lowed by the mild,moderate and severe calcification groups in turn,with statistical differences(P＜0.05).CACS was negatively correlated with serum fetuin-A and MGP levels(r=-0.434,P=0.000;r=-0.512,P=0.000).The poor prognosis group had obviously older age and larger proportions of concomitant frailty syndrome,Killip grade Ⅲ-Ⅳ and coronary artery calcifica-tion,and notable lower serum fetuin-A and MGP levels than the good prognosis group(P＜0.05,P＜0.01).Age and coronary artery calcification were risk factors for poor prognosis in elderly ACS patients(OR=1.386,95％CI:1.227-1.565,P=0.000;OR=16.732,95％CI:4.747-58.968,P=0.000),while serum fetuin-A and MGP were protective factors(OR=0.856,95％CI:0.744-0.986,P=0.032;OR=0.760,95％CI:0.670-0.862,P=0.000).ROC curve analysis showed that the AUC value of fetuin-A and MGP levels and their combination in predicting the prognosis in elderly ACS patients was 0.731,0.841 and 0.928,respectively,and combined the two indicators showed better predictive performance than alone(P＜0.01).Conclusion Serum fetuin-A and MGP levels in elderly ACS patients are associated with the degree of coronary artery calci-fication and prognosis.The two indicators have certain prognostic value for the patients,and their combined detection can further improve the prognostic performance.
