Effect of systemic immune index on myocardial infarction events in elderly patients with coronary heart disease and type 2 diabetes mellitus
10.3969/j.issn.1009-0126.2025.03.006
- VernacularTitle:系统性免疫炎症指数对冠心病合并糖尿病老年患者发生心肌梗死事件的影响
- Author:
Congying WANG
1
;
Kun CHEN
1
;
Lili WANG
1
;
Shuxia CHEN
1
;
Jian GU
1
Author Information
1. 050051 石家庄,河北省人民医院心血管内科
- Publication Type:Journal Article
- Keywords:
coronary disease;
diabetes mellitus;
myocardial infarction;
regression analysis;
athero-sclerosis;
risk factors
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(3):280-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of SII with occurrence of short-term MI in eld-erly patients with CHD complicated with T2DM.Methods A total of 382 CHD patients with con-comitant T2DM admitted in our hospital from January 2022 to January 2023 were enrolled,and according to occurrence of MI within 1 year,they were divided into a MI group(83 patients)and a non-MI group(299 patients).Clinical data were collected,and multivariate logistic regression analysis was used to determine the risk factors for MI in the patients.ROC curve was plotted to evaluate the predictive value of SII,fasting blood glucose(FPG)and their combination for 1-year MI occurrence.Kaplan-Meier curve was drawn to analyze the relationship between SII and MI.Results Multivariate logistic regression analysis showed that SII,FPG and peripheral atheroscle-rosis were risk factors for MI occurrence(OR=1.001,95％CI:1.000-1.001,P=0.001;OR=1.106,95％CI:1.016-1.203,P=0.020;OR=4.798,95％CI:2.621-8.786,P=0.000),and GLP-1RA and SGLT2i were protective factors for the occurrence(OR=0.255,95％CI:0.073-0.895,P=0.033;OR=0.474,95％CI:0.270-0.834,P=0.010).ROC curve analysis indicated showed that the AUC value of SII,FPG and their combination was 0.675,0.619 and 0.702,respectively,and the predictive performance was better in the combination than the indicator alone(P＜0.01).Kaplan-Meier curve analysis revealed that the cumulative survival rate in the high-level group was significantly lower than that in the low-level group(Plog rank＜0.01).Conclusion For the elderly T2DM patients with concomitant CHD,SII,FPG and atherosclerosis are independ-ent risk factors for MI occurrence.SII and FPG have certain predictive value for the occurrence.
