Relationship between serum sST2 and cardiac diastolic function in elderly patients with coronary heart disease and chronic kidney disease
10.3969/j.issn.1009-0126.2025.03.004
- VernacularTitle:老年冠心病合并慢性肾脏病患者血清可溶性生长刺激表达基因2蛋白与心脏舒张功能的关系
- Author:
Huiying LI
1
;
Bing ZHU
;
Lili CAI
;
Shen LIU
;
Hongbin LIU
;
Qiwei ZHU
Author Information
1. 100853 北京,解放军总医院第二医学中心心血管内科国家老年疾病临床医学研究中心
- Publication Type:Journal Article
- Keywords:
coronary disease;
heart;
regression analysis;
clinical study
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(3):270-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum soluble suppression of tumori-genicity 2(sST2)and cardiac diastolic function in elderly patients with coronary heart disease(CHD)and chronic kidney disease(CKD).Methods A total of 116 elderly CHD patients suffer-ing from CKD taking physical examinations at the Second Medical Center of Chinese PLA General Hospital from April 2021 to July 2022 were recruited,and according to their serum sST2 level,they were divided into high sST2 group(＞28.65 μg/L,58 cases)and low sST2 group(≤28.65μg/L,58 cases).The baseline data of all subjected patients were collected,including N-terminal pro-B-type natriuretic peptide(NT-proBNP),as well as peak early diastolic mitral flow velocity(E),peak early diastolic mitral annular velocity(e'),isovolumetric relaxation time(IVRT)and some other indicators in echocardiography.Serum sST2 level was measured using chemilumines-cence assay.Pearson correlation analysis and multiple linear regression analysis were used for analysis.Results The high sST2 group had significantly larger proportion of diabetes and usingβ-blockers,higher levels of sST2,urea and logNT-proBNP,increased left ventricular mass index,thicker left ventricular posterior wall thickness,and elevated E/e'and IVRT,and lower levels of hemoglobin and triacylglycerol,and decreased e'value when compared with the low sST2 group(P＜0.05,P＜0.01).The correlation analysis showed that sST2 was positively correlated with taking β-blockers,urea and logNT-proBNP levels,and E/e'ratio(r=0.226,P=0.015;r=0.362,P=0.001;r=0.374,P=0.001;r=0.257,P=0.005),and negatively correlated with triglycerides,hemoglobin and e'value(r=-0.227,P=0.014;r=-0.314,P=0.001;r=-0.203,P=0.029).Multiple linear regression analysis displayed that sST2 was linearly correlated with triglycerides,urea and NT-proBNP levels,and E/e'(P＜0.05,P＜0.01).Conclusion Serum sST2 level is cor-related with cardiac diastolic function in elderly patients with comorbidities of CHD and CKD.
