Role of mitochondrial homeostasis in the pathogenesis of rheuma-toid arthritis
10.12092/j.issn.1009-2501.2025.04.013
- VernacularTitle:线粒体稳态在类风湿关节炎致病中的作用
- Author:
Dongye JIA
1
;
Zhi PAN
1
Author Information
1. 长春中医药大学人参科学研究院,长春 130117,吉林
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
mitochondrial homeostasis;
mitochondrial dynamics;
energy me-tabolis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(4):541-547
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease that can affect joints and extra-articular organs,including the heart,kidneys,lungs,digestive system,eyes,skin,and nervous system.During RA,mitochondrial ho-meostasis is altered,leading to the production of inflammatory mediators and joint damage by af-fecting cartilage and synovial tissues.Regulating mi-tochondrial homeostasis is a key step in slowing the progression of RA.This study conducts a com-prehensive literature review on the topics of"rheu-matoid arthritis"and"mitochondrial homeostasis"over the past decade.It aims to summarize and an-alyze the factors contributing to mitochondrial ho-meostasis imbalance in RA,as well as the potential role of modulating mitochondrial homeostasis in ameliorating RA,with the ultimate goal of offering novel insights and approaches for RA treatment.
