Clinical effects of oral administration and enema of Tongfu Paiqi Mixture on patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction
10.3969/j.issn.1001-1528.2025.02.015
- VernacularTitle:通腑排气合剂内服、灌肠对慢性阻塞性肺疾病急性加重期伴胃肠功能障碍患者的临床疗效
- Author:
Li-na MAO
1
;
Pei-lin XIE
1
;
Ying HUANG
1
;
Shuo YANG
1
Author Information
1. 武汉市中西医结合医院(武汉市第一医院),湖北武汉 430022
- Publication Type:Journal Article
- Keywords:
Tongfu Paiqi Mixture;
oral administration;
enema;
conventional treatment;
acute exacerbation of chronic obstructive pulmonary disease;
gastrointestinal dysfunction;
gastrointestinal hormones;
inflammatory factors
- From:
Chinese Traditional Patent Medicine
2025;47(2):457-462
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of oral administration and enema of Tongfu Paiqi Mixture on patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction.METHODS One hundred and eight patients were randomly assigned into control group(54 cases)for 5-day intervention of both oral administration and enema of Tongfu Paiqi Mixture simulant and conventional treatment,and observation group(54 cases)for 5-day intervention of both oral administration and enema of Tongfu Paiqi Mixture and conventional treatment.The changes in clinical effects,GIDS score,Phlegm and Blood Stasis Obstructing Lung Syndrome score,gastrointestinal mucosal barrier serum markers(DAO,D-LA,IFABP),intra-abdominal pressure,gastrointestinal hormones(MTL,GAS,VIP),inflammatory factors(IL-1β,IL-6,TNF-α,PCT),pulmonary function indices(FEV1、FEV1％)and PaO2/FiO2 were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased GIDS score,Phlegm and Blood Stasis Obstructing Lung Syndrome score,intra-abdominal pressure,VIP,gastrointestinal mucosal barrier serum markers,inflammatory factors(P＜0.05),and increased MTL,GAS,pulmonary function indices,PaO2/FiO2(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction,the oral administration and enema of Tongfu Paiqi Mixture can regulate gastrointestinal hormones,reduce inflammatory degree,protect intestinal barrier functions,alleviate clinical symptoms,and improve pulmonary functions.
