Association of postoperative biliary tract infection with expressions of sCD14-ST,PCT,TLR4 and TLR2 in peripheral blood of malignant obstructive jaundice patients undergoing PTCD
10.11816/cn.ni.2025-240565
- VernacularTitle:恶性梗阻性黄疸PTCD术后胆道感染与外周血sCD14-ST、PCT、TLR4 和TLR2表达的关联
- Author:
Jiyao YAO
1
;
Yu GONG
1
;
Jing WANG
1
;
Li FENG
1
;
Xu CHU
1
Author Information
1. 中国医科大学附属盛京医院胆道整形美容外科,辽宁沈阳 110136
- Publication Type:Journal Article
- Keywords:
Malignant obstructive jaundice;
Percutaneous transhepatic cholangial drainage;
Biliary tract infection;
Soluble cluster of differentiation 14 subtype;
Procalcitonin;
Toll-like receptor;
Pathogen
- From:
Chinese Journal of Nosocomiology
2025;35(5):672-676
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the association of postoperative biliary tract infection with expressions of soluble cluster of differentiation 14 subtype(sCD14-ST),procalcitonin(PCT),Toll-like receptor(TLR)4 and TLR2 in malignant obstructive jaundice(MOJ)patients undergoing percutaneous transhepatic cholangial drainage(PTCD).METHODS A total of 105 MOJ patients who underwent PTCD in Shengjing Hospital Affiliated to China Medical University form Nov.2021 to Nov.2023 were enrolled in the study and were divided into the infection group with 31 cases and the non-infection group with 74 cases according to the status of postoperative biliary tract infection.The etiological characteristics and drug resistance rates of the infection group were statistically analyzed.The levels of peripheral blood sCD14-ST,PCT,TLR4 and TLR2 were compared between the two groups,and the values of sCD14-ST,PCT,TLR4 and TLR2 in diagnosis of postoperative biliary tract infection in the MOJ patients under-going PTCD wee analyzed.RESULTS Totally 53 strains of pathogens were isolated from 31 patients of the infec-tion group,among which gram-negative bacteria were dominant.Escherichia coli and Enterococcus faecalis were respectively the major species of the gram-negative and gram-positive bacteria.The E.coli was mainly resistant to ampicillin and sensitive to imipenem;the E.faecalis was mainly resistant to ciprofloxacin,tetracycline,erythro-mycin and was sensitive to vancomycin.There were significant differences in the levels of sCD14-ST,PCT,TLR4 and TLR2 between the two groups(P＜0.05);the sCD14-ST level of the infection group was(41.12±13.14)ng/ml,higher than(29.35±9.17)ng/ml of the non-infection group(t=5.248,P＜0.001).The area under the curve(AUC)value of the joint detection of sCD14-ST,PCT,TLR4 and TLR2 was higher than that of the single detec-tion in diagnosis of postoperative biliary tract infection in the MOJ patients undergoing PTCD(P＜0.05).CONCLUSIONS The gram-negative bacteria are the major pathogens isolated from the MOJ patients with postop-erative biliary tract infection.Imipenem and vancomycin are recommended for treatment of the E.coli and E.fae-calis infections.The patients show abnormal expressions of sCD14-ST,PCT,TLR4 and TLR2.The joint detec-tion of the four indexes has high diagnostic value.
