Values of G test and lymphocyte subsets in diagnosis of Pneumocystis jirovecii pneumonia in immunocompromised patients
10.11816/cn.ni.2025-240973
- VernacularTitle:G试验和淋巴细胞亚群对免疫功能低下合并耶氏肺孢子菌肺炎的诊断价值
- Author:
Xianming QIU
1
;
Peng XU
;
Lei ZHOU
;
Hao HAO
;
Li KONG
Author Information
1. 山东第一医科大学第一附属医院重症医学科,山东济南 250014
- Publication Type:Journal Article
- Keywords:
Immunocompromised;
Pneumocystis jirovecii pneumonia;
G test;
Lymphocyte subs
- From:
Chinese Journal of Nosocomiology
2025;35(6):854-857
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the clinical data of the immunocompromised patients complicated with Pneumo-cystis jirovecii pneumonia(PJP)and explore the values of G test and lymphocyte subsets in diagnosis of the PJP in the immunocompromised patients.METHODS A total of 78 immunocompromised patients who were treated in respiratory intensive care unit of the First Affiliated Hospital of Shandong First Medical University from Jan.2019 to Dec.2021 wee recruited as the research subjects,39 of whom had PJP and were assigned as the PJP group,39 did not have PJP and were assigned as the non-PJP group.The clinical data were compared between the two groups.The values of the clinical laboratory test indexes in diagnosis of PJP in the immunocompromised patients were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS The mortality rate of the PJP group was higher than that of the non-PJP group(P＜0.05).There were significant differences in the white blood cell(WBC)counts,neutrophils(Neu)counts,platelet distribution width(PDW),procalcitonin(PCT),C-reac-tive protein(CRP)and GM test between the PJP group and the non-PJP group;the G test was(1843.59±1621.41)pg/ml in the PJP group,(87.15±111.01)pg/ml in the non-PJP group;the percentage of CD8 lympho-cyte was(36.22±19.34)％in the PJP group,(25.99±13.10)％in the non-PJP group,and there were significant differences(P＜0.05).The areas under the curves(AUCs)of the G test and the percentage of CD8 lymphocyte were respectively 0.981 and 0.714 in diagnosis of PJP in the immunocompromised patients,and the cutoff values were 368.40 pg/ml and 31.30％,respectively.CONCLUSIONS It is necessary for the clinicians to pay great attention to the high mortality rate of the immunocompromised patients complicated with severe pneumonia.The G test and the percentage of CD8 lymphocyte have certain values in diagnosis of PJP in the immunocompromised patients.
