A Mendelian randomization study of relationship between maternal smoking around birth and offspring psychiatric disorders
10.3969/j.issn.1000-6729.2025.03.03
- VernacularTitle:母亲分娩前后吸烟与后代精神疾病关系的孟德尔随机化研究
- Author:
Bei ZHANG
1
;
Zheng ZHANG
;
Hao REN
;
Xinglian WANG
;
Haitang QIU
;
Zehui LI
;
Yanwei LI
;
Chenggang JIANG
;
Qinghua LUO
Author Information
1. 重庆医科大学附属第一医院精神科,重庆 400016;重庆市渝中区精神卫生中心精神康复医学科,重庆 400014
- Publication Type:Journal Article
- Keywords:
smoking;
attention deficit hyperactivity disorder;
bipolar disorder;
depression;
Mendelian ran-domization
- From:
Chinese Mental Health Journal
2025;39(3):207-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causal impact of maternal smoking around birth(MSAB)on off-spring's risk of attention deficit hyperactivity disorder(ADHD),autism spectrum disorder(ASD),bipolar disorder(BD),and major depressive disorder(MDD).Methods:The datasets for MSAB and 4 psychiatric disorders were extracted from genome-wide association studies(GWAS).Mendelian randomization(MR)was employed,using in-verse variance weighting(IVW)as the primary analysis method.Sensitivity analyses and outlier correction were conducted using weighted median(WM),MR-Egger regression,and MR-PRESSO.The results were expressed as odds ratios(OR)and corrected for false discovery rate(FDR).Results:MR analysis showed significant causal re-lationships between MSAB and increased risk of ADHD(OR=5.36,95％CI=2.58-7.63,PFDR=0.003),MDD(OR=1.92,95％CI=1.29-2.88,PFDR=0.003),and BD(OR=6.33,95％CI=1.56-8.73,PFDR=0.013).However,no statistically significant association was found between MSAB and ASD(OR=1.66,95％CI=0.23-5.87,PFDR=0.616).Conclusion:This study suggests a potential causal link between maternal smoking around the time of birth and an increased risk of attention deficit hyperactivity disorder,bipolar disorder,and major depressive disorder in offspring.
