Recurrent hepatocellular carcinoma after liver transplantation developed into a special molecular and histopathological transformation:one case report
10.3781/j.issn.1000-7431.2024.2408-0481
- VernacularTitle:高分化肝细胞癌患者肝移植后肿瘤复发转化为低分化癌以及表现为特殊分子遗传学特征:1例报道
- Author:
Zebing LIU
1
;
Yanying SHEN
;
Hao FENG
;
Jie CAO
Author Information
1. 上海交通大学医学院附属仁济医院病理科,上海 200127
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Liver transplantation;
Recurrence of tumor;
Pathologic diagnosis;
Genomic change
- From:
Tumor
2024;44(8):885-890
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the special molecular and histopathological transformation of recurrent tumor in a patient with primary hepatocellular carcinoma(HCC)after liver transplantation.Methods:A case of HCC had recurrent tumor presenting special molecular and histopathological characteristics after liver transplantation.The diagnosis and treatment process of this case is reported.Results:A case of highly differentiated HCC received immune checkpoint inhibitors combined with antiangiogenic therapy after liver malignant tumor resection.Nearly one year later,due to severe liver cirrhosis,the case accepted allogeneic orthotopic transplantation of liver.More than two years later,elevated level of serum alpha fetoprotein was detected,then the PET-CT examination showed multiple suspected lesions with increased 18F-FDG metabolism in the right lobe of the liver.Liver biopsy and high-throughput sequencing were performed,and the results revealed poorly differentiated HCC with YAP1-MAML2 fusion gene.Chemotherapy with XELOX regimen and radiotherapy were administered,and no tumor progression was observed during follow-up.Conclusion:Recurrent tumors after liver transplantation in HCC patient developing into a special molecular and histopathological transformation is rarely reported.The underlying mechanism could be the dramatical alterations of immune microenvironment after liver transplantation,which consequently triggered genomic changes leading to generate novel YAP1-MAML2 fusion gene.The poor differentiation transformation after liver transplantation maybe driven by YAP1-MAML2 fusion gene.
