Research progress of LncRNA SNHG6 in digestive system tumors

VernacularTitle:LncRNA SNHG6在消化系统肿瘤中作用的研究进展
Author: Yani ZHANG ¹ ; Lingling ZHU ; Yujing HE ; Tingting SHI ; Yang WU ; Chun GAO ; Jiucong ZHANG
Author Information

1. 甘肃中医药大学第一临床医学院,甘肃兰州 730000;中国人民解放军联勤保障部队第九四○医院消化内科,甘肃兰州 730050
Publication Type:Journal Article
Keywords: Digestive system tumors; lncRNA; SNHG6; Chemotherapy resistance; Mechanism
From: Tumor 2024;44(8):878-884
CountryChina
Language:Chinese
Abstract: Digestive system tumors are malignant tumors with high malignancy,easy metastasis,and poor prognosis,which are difficult to diagnose due to the insidious onset.Most of the patients have reached the middle and advanced stages at the time of diagnosis,so the effect of treatment is usually not good.Studies have shown that the long non-coding RNA(lncRNA)small nucleolar RNA host gene 6(SNHG6)is highly expressed in a variety of solid tumors,and can participate in malignant biological processes such as tumor proliferation,invasion and migration.SNHG6 is closely related to the emergence of chemotherapy drug resistance.This article reviews the biological function and clinical significance of SNHG6 in 6 different tumors of the digestive system,and discusses its mechanism of action in tumorigenesis and development,in the hope to search for effective early diagnosis and treatment targets and thereby improve the survival rate of cancer patients.