Effects of UpToDate-based early-warning model on toxic side effects and disease uncertainty in patients receiving postoperative chemotherapy for breast cancer
10.3781/j.issn.1000-7431.2024.2403-0142
- VernacularTitle:基于UpToDate预警模式对乳腺癌术后化疗患者不良反应和疾病不确定感的影响
- Author:
Haiyan QI
1
;
Yanhong LI
;
Yanni TIAN
;
Huimin DONG
;
Lei ZHANG
;
Xueliang ZHANG
;
Genhui AN
Author Information
1. 甘肃省肿瘤医院放疗科,甘肃 兰州 730050
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Chemotherapy;
Warning mode based on UpToDate;
Adverse reaction;
Disease uncertainty
- From:
Tumor
2024;44(8):861-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact of the early warning model based on UpToDate on the adverse reactions and disease uncertainty of patients receiving AC-T chemotherapy after breast cancer surgery.Methods:Two hundred patients with breast cancer who received AC-T chemotherapy after surgery in Gansu Cancer Hospital from October 2020 to October 2022 were included and randomly divided into control group and observation group(100 cases each).Both groups of patients underwent surgical treatment and received AC-T chemotherapy after surgery.During the treatment period,the control group received routine specialized nursing care,while the observation group received a warning mode based on UpToDate,with continuous intervention for 3 months.The psychological status,Hamilton anxiety scale(HAMA),Hamilton depression rating scale(HAMD),medical uncertainty inventory scale(MUIS),and European Organization for Research and Treatment of Cancer quality of life questionnaire core-30(EORTC-QLQ-C30)scores and adverse reactions between two groups were compared.Results:After 3 months of intervention,the HAMA,HAMD and MUIS scores of the observation group were 14.39±2.70,10.91±2.22 and 66.36±7.55,respectively,which were significantly lower than those of the control group(17.76±4.15,15.62±3.34 and 76.23±10.31,respectively),and the differences were statistically significant(all P＜0.05).The total quality of life score of the observation group was 81.23±13.26,which was higher than that of the control group(73.69±8.45)(P＜0.05).In the symptom scale,the fatigue,malignancy,vomiting,and pain scores of the observation group were 18.75±3.34,24.72±5.18 and 22.26±3.04,respectively,which were lower than those of the control group(29.03±6.07,35.07±8.15 and 28.31±5.16,respectively)(all P＜0.05).In the individual test,the insomnia score of the observation group was 18.65±3.37,which was lower than that of the control group(22.60±5.24)(P＜0.05).The incidence rates of nausea and vomiting,decreased appetite,abdominal pain and diarrhea,and decreased blood cells in the observation group were lower than those in the control group(all P＜0.05).Conclusion:The early warning mode based on UpToDate can improve the psychological status of breast cancer patients receiving chemotherapy after surgery,reduce adverse reactions and the uncertainty of disease,and improve the quality of life.
