Distribution and drug resistance of pathogens isolated from neonates with purulent meningitis and risk factors for prognosis
10.11816/cn.ni.2025-240484
- VernacularTitle:新生儿化脓性脑膜炎病原菌和耐药性及预后危险因素
- Author:
Lei YANG
1
;
Weiyun LIU
;
Anhui HU
;
Xiaohua HU
Author Information
1. 江西省新余市妇幼保健院新生儿科,江西新余 338000
- Publication Type:Journal Article
- Keywords:
Neonate;
Purulent meningitis;
Pathogen;
Drug resistance;
Prognosis;
Risk factor
- From:
Chinese Journal of Nosocomiology
2025;35(5):713-717
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the distribution and drug resistance of pathogens isolated from the neonates with purulent meningitis and analyze the risk factors for prognosis.METHODS A total of 80 neonates with puru-lent meningitis who were treated in Maternity and Child Care Center of Xinyu and Xinyu People's Hospital from Jan.2020 to Dec.2022 were recruited as the research subjects.The distribution and drug resistance of the patho-gens isolated from the patients were observed.The neonates were divided into the poor prognosis group with 31 cases and the favorable prognosis group with 49 cases according to the treatment outcomes at the discharge from the hospital.The clinical data were compared between the two groups.The risk factors for the prognosis were ana-lyzed.RESULTS Totally 84 strains of pathogens were isolated from 80 children,the gram-positive bacteria accoun-ted for 36.90％,mainly including Staphylococcus epidermidis,Staphylococcus haemolyticus,Staphylococcus saprophyticus and Staphylococcus hominis;The gram-negative bacteria accounted for 63.10％,mainly including Escherichia coli and Klebsiella pneumoniae.The drug resistance rates of the major species of gram-positive bacte-ria to oxacillin,penicillin,cefoxitin and clindamycin were high.The drug resistance rates of the major species of gram-negative bacteria to levofloxacin,gentamycin and ceftriaxone were high.The drug resistance rates of the K.pneumoniae strains to gentamycin,levofloxacin and tobramycin were high.The proportion of neonates with coma and the total protein level of cerebrospinal fluid were higher in the poor prognosis group than in the favorable prog-nosis group(P＜0.05);the cerebrospinal fluid glucose level of the poor prognosis group was lower than that of the favorable prognosis group(P＜0.05).Coma,high level of total protein in cerebrospinal fluid and low level of cere-brospinal fluid glucose were the risk factors for the poor prognosis(P＜0.05).CONCLUSIONS The gram-negative bacteria are dominant among the pathogens isolated from the neonates with purulent meningitis.The coma,total protein of cerebrospinal fluid and cerebrospinal fluid glucose are the risk factors for the poor prognosis.It is neces-sary for the hospital to rational use of antibiotics based on the results of culture of pathogens and drug susceptibili-ty testing and take intervention measures to the risk factors for the prognosis.
