Correlation between peripheral blood mitochondrial DNA and urine microalbumin in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.04.002
- VernacularTitle:2型糖尿病患者外周血线粒体DNA与尿微量白蛋白相关性的研究
- Author:
Da CHEN
1
;
Juli ZENG
;
Chenxia ZHOU
;
Ziyi LI
;
Bo FENG
;
Jun SONG
Author Information
1. 200120 上海,同济大学附属东方医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Diabetic kidney disease;
Mitochondrial DNA;
Urinary microalbumin
- From:
Chinese Journal of Diabetes
2025;33(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between peripheral blood mitochondrial DNA(mtDNA)copy number and urinary microalbumin(MAlb)in patients with type 2 diabetes mellitus(T2DM).Methods 87 patients with T2DM from the Endocrinology Department of East Hospital of Tongji University were selected based on inclusion criteria.According to urinary MAlb levels,patients were divided into T2DM group(MAlb＜30 mg/L)and MAlb group(MAlb＞30 mg/L).General patient information was collected,and clinical indicators such as blood glucose,lipid profile,glycated hemoglobin and insulin were measured.Peripheral blood mtDNA was extracted and the copy number was detected using real-time quantitative polymerase chain reaction(RT-PCR).Logistic regression analysis was used to identify the risk factors for albuminuria.Results Compared with T2DM group,DM duration,serum creatinine,serum uric acid and copy number of mtDNA in MAlb group increased(P＜0.05),while high density lipoprotein cholesterol decreased(P＜0.05).Logistic analysis showed that the copy number of mtDNA was the influencing factor of MAlb in T2DM patients.Conclusions The peripheral blood mtDNA copy number in T2DM patients is positively correlated with urinary microalbumin,thus providing a potential target for early detection of DKD.
