Expressions of Apo B/A1 and PCT in peripheral blood of acute pancreatitis patients with infectious pancreatic necrosis
10.11816/cn.ni.2025-240717
- VernacularTitle:急性胰腺炎感染性胰腺坏死外周血Apo B/A1和PCT表达及其预测价值
- Author:
Fang XU
1
;
Xiao LIU
;
Junfeng QIAN
;
Zengli ZHOU
;
Yong QIN
Author Information
1. 丽水市人民医院消化内科,浙江丽水 323000
- Publication Type:Journal Article
- Keywords:
Apolipoprotein B/apolipoprotein A1;
Procalcitonin;
Acute pancreatitis;
Infectious pancreatic necrosis
- From:
Chinese Journal of Nosocomiology
2025;35(6):850-853
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the expressions of apolipoprotein B/apolipoprotein A1(Apo B/A1)and procalci-tonin(PCT)in peripheral blood of the acute pancreatitis(AP)patients with infectious pancreatic necrosis(IPN)and analyze the predictive values.METHODS A total of 102 patients with AP who were treated in Lishui People's Hospital from Jan.2022 to Dec.2023 were recruited as the research subjects and were divided into the IPN group with 29 cases and the non-IPN group with 73 cases according to the status of IPN.The baseline data of the two groups of patients were analyzed,the expression levels of Apo B/A1,PCT and other serologic indexes were ob-served and compared between the two groups.The values of peripheral blood Apo B/A1 and PCT in prediction of IPN in the AP patients were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS There were no significant differences in the baseline data such as age and gender between the two groups of pa-tients.There were significant differences in the expression levels of peripheral blood Apo B/A1,PCT and RDW as well as blood calcium level between the IPN group and the non-IPN group(P＜0.05);the expression levels of pe-ripheral blood Apo B/A1 and PCT of the IPN group were respectively(2.54±0.75)and(11.77±3.21)ng/ml,higher than those of the non-IPN group(t=8.712,12.095,all P＜0.001);the blood calcium level of the IPN group was(2.22±0.22)mmol/L,lower than that of the non-IPN group(t=2.749,P=0.007).There were no sig-nificant differences in other serologic indexes.ROC curve analysis showed that both the single and joint detection of peripheral blood Apo B/A1 and PCT had the predictive efficiency for IPN in the AP patients(P＜0.05),the ar-eas under the curves(AUCs)were 0.886,0.874 and 0.922,respectively;the efficiency of the joint detection of the two indexes was the highest,with the sensitivity 82.72％,the specificity 86.30％.CONCLUSIONS The peripheral blood Apo B/A1,PCT,RDW and blood calcium are the influencing factors for the IPN in the AP patients.The joint detection of Apo B/A1 and PCT can predict the IPN for the AP patients in early stage.
