Assessment of glymphatic system function in mild traumatic brain injury patients based on diffusion tensor imaging analysis along the perivascular space index
10.3969/j.issn.1002-1671.2025.04.002
- VernacularTitle:基于血管周围间隙扩散张量成像分析指数评估轻型脑外伤患者类淋巴系统功能
- Author:
Guihan YANG
1
;
Xiaofeng CHEN
;
Junliang DENG
;
Yulin LIN
;
Liqiang DAI
;
Xiangguang CHEN
;
Zhiqi YANG
Author Information
1. 梅州市人民医院放射科,广东 梅州 514031
- Publication Type:Journal Article
- Keywords:
diffusion tensor imaging;
glymphatic system;
traumatic brain injury
- From:
Journal of Practical Radiology
2025;41(4):544-548
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of glymphatic system in patients with mild traumatic brain injury via diffusion tensor imaging analysis along the perivascular space(DTI-ALPS)index and its relationship with clinical features.Methods The clinical and imaging data from 163 patients with mild traumatic brain injury were retrospectively collected,including 31 cases with MRI-negative findings and 132 cases with MRI-positive findings.In addition,29 healthy individuals underwent physical examinations were included as a control group.The differences in DTI-ALPS index and clinical features between mild traumatic brain injury and control group,as well as among subgroups of traumatic brain injury were analyzed.Results The DTI-ALPS index in patients with mild traumatic brain injury were significantly higher than those in control group(P＜0.05).Subgroup analysis showed that DTI-ALPS index of traumatic brain injury patients with MRI-negative findings and MRI-positive findings were all significantly higher than those of control group(P=0.023 and 0.004,respectively).Compared to control group,DTI-ALPS index in mild traumatic brain injury patients gradually increased with the progression of injury,and the difference was statistically significant(P=0.008).Conclusion Patients with mild traumatic brain injury exhibit increased functional activity of glymphatic system,as indicated by increased DTI-ALPS index,which further increase with the progression of injury.
