18 F-PSMA-1007 PET/MRI for diagnosing seminal vesicle invasion of prostatic cancer
10.13929/j.issn.1003-3289.2025.02.027
- VernacularTitle:18F-PSMA-1007 PET/MRI诊断前列腺癌侵犯精囊腺
- Author:
Yingying LUO
1
;
Yihong YANG
;
Zhiwen YOU
;
Xing CHEN
;
Zirong ZHOU
;
Zengbei YUAN
;
Haifeng WANG
;
Jun ZHAO
;
Haiyan WANG
Author Information
1. 同济大学附属东方医院核医学科,上海 200120
- Publication Type:Journal Article
- Keywords:
prostatic neoplasms;
seminal vesicles;
positron-emission tomography;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):310-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of 18F-prostate specific membrane antigen(PSMA)-1007 PET/MRI for diagnosing seminal vesicle invasion(SVI)of prostatic cancer(PCa).Methods Totally 92 male patients with PCa who underwent radical prostatectomy were retrospectively enrolled and divided into positive group(n=26)and negative group(n=66)based on postoperative pathology showed SVI or not.PET/MRI parameters,including maximum standard uptake value(SUVmax),minimum apparent diffusion coefficient(ADCmin),mean apparent diffusion coefficient(ADCmean),SUVmax/ADCmin,SUVmax/ADCmean,PSMA tumor volume(PSMA-TV)and total lesion PSMA(TL-PSMA)were compared between groups.The receiver operating characteristic curve was drawn,and the efficacy of each parameter for diagnosing SVI was analyzed.Results Among 92 cases of PCa,18F-PSMA-1007 PET/MRI showed 30 cases with SVI and 62 cases without SVI,with accuracy of 73.91％,sensitivity of 61.54％,specificity of 78.79％,positive predictive value of 53.33％and negative predictive value of 83.87％.Significant differences of ADCmin,PSMA-TV and TL-PSMA were found between groups(all P＜0.05).The area under the curve(AUC)of SUVmax,ADCmin,ADCmean,SUVmax/ADCmin,SUVmax/ADCmean,PSMA-TV and TL-PSMA for diagnosing SVI of PCa was 0.554,0.341,0.396,0.603,0.581,0.755 and 0.705,respectively.The AUC of PSMA-TV was higher than other parameters except for TL-PSMA,with sensitivity of 84.60％and specificity of 56.10％.Conclusion 18 F-PSMA-1007 PET/MRI was helpful for diagnosing SVI of PCa.
