Mesial temporal lobe epilepsy:revealing the abnormal patterns of individual structural covariance networks
10.3969/j.issn.1002-1671.2025.04.001
- VernacularTitle:内侧颞叶癫痫:揭示个体结构协变网络的异常模式
- Author:
Ziyu DIAO
1
;
Hongzhuo WANG
1
;
Donglin WU
1
;
Shijun QIU
1
;
Jie AN
1
Author Information
1. 广州中医药大学第一附属医院(广东省中医临床研究院)影像科,广东 广州 510405
- Publication Type:Journal Article
- Keywords:
mesial temporal lobe epilepsy;
individual structural covariance network;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(4):539-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of brain imaging changes in patients with mesial temporal lobe epilepsy(mTLE)based on individual structural covariance networks of gray matter volume.Methods A total of 74 mTLE patients,including 39 patients in the left mTLE group and 35 patients in the right mTLE group,along with 46 healthy controls(control group),had completed 3D T1WI structural imaging scans.The network template perturbation approach was used to analyze the individualized structural covariance networks in patients with mTLE.Results Compared with the control group,the left and right mTLE groups showed decreased structural covariance connections for the ipsilateral hippocampus to the contralateral hippocampus and parahippocampal gyrus,orbitofrontal gyrus,middle frontal gyrus,superior parietal gyrus,amygdala and fusiform gyrus.In addition,increased structural covariation connections was mainly distributed in the bilateral frontal lobe,parietal lobe,temporal lobe,occipital lobe and paralimbic system in the right mTLE group,whereas increased structural covariation connections was mainly located within the left frontal lobe,parietal lobe and occipital lobe in the left mTLE group(P＜0.05).Compared with the left mTLE group,the right mTLE group showed decreased structural covariance connections with the ipsilateral hippocampus as a core node(P＜0.05).Conclusion Compared with the left mTLE group,the right mTLE group showed more pronounced decreased structural covariance connections centered around the ipsilateral hippocampus,as well as a more intricate compensatory mechanism.The pattern of the individual structural covariance networks in mTLE patients not only contribute to understanding of its pathogenesis but also served as a potential biomarker for clinical diagnosis.
