Synthetic MRI for evaluating structural changes of brain nuclei and white matter in patients with Parkinson disease
10.13929/j.issn.1003-3289.2025.02.012
- VernacularTitle:合成MRI评估帕金森病患者脑部核团及白质结构改变
- Author:
Man WANG
1
;
Jinghan ZHAO
1
;
Bingbing GAO
1
;
Mingrui QU
1
;
Yanwei MIAO
1
Author Information
1. 大连医科大学附属第一医院放射科,辽宁大连 116011
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
brain;
magnetic resonance imaging;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):239-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of synthetic MRI(syMRI)for evaluating structural changes of brain nuclei and white matter in patients with Parkinson disease(PD).Methods Forty-five PD patients(PD group)and 35 healthy controls(HC group)were prospectively enrolled.Head scanning with strategically acquired gradient echo sequence was performed,then syMRI was obtained with post-processing.The values of T1,proton density(PrD),R2* and magnetic sensitivity values(MSV)of nuclei and white matter were measured based on syMRI and compared between groups.The correlations of syMRI quantitative parameters of nuclei and white matter being significantly different between groups with neurological function scores of subject were analyzed,and a combined model was established using multivariate logistic regression analysis.Receiver operating characteristic(ROC)curve was drawn,the efficacy of single syMRI quantitative parameter and combined model for diagnosing PD was evaluated.Results Compared with HC group,T1 and PrD values of bilateral caudate nuclei decreased,while MSV of bilateral substatia nigra and right red nucleus increased(all FDR correction P＜0.05),while T1 and PrD values of bilateral splenium of corpus callosum,PrD values of left posterior limbs of the internal capsule(PLIC),R2* values of bilateral PLIC and right genu of the corpus callosum decreased in PD group(all FDR correction P＜0.05).syMRI quantitative parameters of the above brain regions were correlated with scores of Montreal cognitive assessment and Hamilton anxiety scale(r=-0.390-0.416,all P＜0.01).The area under the curve of single syMRI quantitative parameter for diagnosing PD was 0.664-0.788,lower than that of combined model(0.905,Z=2.653-4.096,all P＜0.05).Conclusion SyMRI could be used to quantitatively evaluate structural changes of brain nuclei and white matter in PD patients.
