Advances in research on the interaction mechanisms between androgen receptor and PI3K/AKT pathways in prostate cancer
10.3969/j.issn.1006-7795.2025.02.013
- VernacularTitle:雄激素受体与PI3K/AKT通路相互作用机制在前列腺癌中的研究进展
- Author:
Tianyu XIONG
1
;
Youquan ZHAO
;
Ping XIE
;
Yinong NIU
Author Information
1. 首都医科大学附属北京友谊医院泌尿外科,北京 100050;北京市卫生健康委员会泌尿外科研究所,北京 100050
- Publication Type:Journal Article
- Keywords:
prostate cancer;
androgen receptor;
PI3K;
AKT;
signaling pathway
- From:
Journal of Capital Medical University
2025;46(2):269-282
- CountryChina
- Language:Chinese
-
Abstract:
Both the androgen receptor pathway and PI3K/AKT pathway play pivotal roles in the progression of prostate cancer.There are intricate interactions between these two pathways,showing a negative regulatory relationship of mutual restriction between them.In view of the above,a combined inhibition strategy targeting these two pathways is expected to become a significant therapeutic approach for prostate cancer.This article aims to comprehensively review the molecular mechanisms underlying the interactions between the androgen receptor and PI3K/AKT pathways,to provide new perspectives and insights for research in the fields.
