Mendelian randomization study of causality between opioids and chronic renal failure
10.3969/j.issn.1673-9701.2025.03.005
- VernacularTitle:阿片类药物和慢性肾衰竭因果关系的孟德尔随机化研究
- Author:
Jingjing SHI
1
;
Wenyuan LIU
Author Information
1. 山西医科大学第一医院万柏林分院肾内科,山西太原 030024
- Publication Type:Journal Article
- Keywords:
Opioids;
Chronic renal failure;
Causal relationship;
Mendelian randomization
- From:
China Modern Doctor
2025;63(3):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential causal relationship between opioids and chronic renal failure(CRF)using Mendelian randomization analysis.Methods Screening for single nucleotide polymorphisms(SNPs)strongly associated with opioids and CRF firstly,causality was analyzed by using two-sample Mendelian randomization methods,heterogeneity,horizontal pleiotropy and sensitivity analyses were then performed.Results A total of 41 opioid-related SNPs were screened in this study,inverse variance weighting analysis suggested that opioid use is a risk factor for CRF(OR=1.15,95％CI:1.04-1.27,P＜0.01).The heterogeneity test showed that there was no heterogeneity in the SNPs,and the horizontal multivariate analysis and sensitivity analysis confirmed the robustness of the results.Conclusion Genetically,the study suggests a positive causal association between opioids and CRF,opioid use is a risk factor for CRF.
