Correlations of early brain microstructural changes and cognitive function in patients with alcohol use disorder
10.13929/j.issn.1003-3289.2025.02.009
- VernacularTitle:酒精使用障碍患者早期脑微结构改变与认知功能的相关性
- Author:
Yijin YAN
1
;
Chenyang WANG
;
Yan GAO
;
Yanchi LIU
;
Jiawen DONG
;
Jie LI
;
Hongzeng ZHAO
Author Information
1. 新乡医学院第二附属医院放射介入科,河南新乡 453002
- Publication Type:Journal Article
- Keywords:
alcohol-related disorders;
cerebral cortex;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):224-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the early brain microstructural changes in patients with alcohol use disorder(AUD)and the correlations with cognitive function.Methods Totally 81 AUD patients(AUD group)and 75 healthy volunteers(control group)were retrospectively enrolled.Gray matter volume(GMV)and cortical thickness of brain regions were calculated with voxel-based morphometry and surface-based morphometry,and the correlations of the above indexes of brain regions being significantly different between groups and clinical cognitive function scale scores were analyzed.Results In AUD group,GMV of bilateral hippocampus,insula,inferior parietal angular gyrus,straight gyrus,central posterior gyrus and cerebellar angle 1 area,of left medial superior frontal gyrus,precuneus,anterior cingulated cortex,middle temporal gyrus and middle occipital gyrus,as well as of right lingual gyrus reduced significantly compared with those in control group.The cortical thickness of bilateral superior frontal gyrus,middle frontal gyrus,inferior frontal gyrus,supramarginal gyrus,superior parietal lobule,inferior parietal lobule,central posterior gyrus,central anterior gyrus,temporal superior gyrus and middle temporal gyrus reduced in AUD group.In AUD group,GMV of left medial superior frontal gyrus was positively correlated with Pittsburgh sleep quality index score(r=0.301,P=0.006),while of the left and right straight gyrus were positively correlated with Hopkins verbal learning test-revised score(r=0.328,0.326;both P=0.003)but negatively correlated with trail making test-B score(r=-0.295,-0.312;P=0.008,0.005),while the cortical thickness of the left central anterior gyrus and the lower part of the right middle frontal gyrus were positively correlated with Beck anxiety inventory score(r=0.323,0.289;P=0.003,0.009).Conclusion Prefrontal cortex atrophy could be observed in early stage AUD patients,which was correlated with cognitive function impaired.
